2,3,5,6-Tetrafluoro-1,4-benzenedimethanol

Base Information

• Chemical Name: 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol
• CAS No.: 92339-07-6
• Molecular Formula: C8H6F4O2
• Molecular Weight: 210.128
• Hs Code.: 2907199090
• European Community (EC) Number: 814-676-7
• DSSTox Substance ID: DTXSID70399296
• Nikkaji Number: J1.797.218I
• Wikidata: Q72505069
• Mol file: 92339-07-6.mol

Synonyms:2,3,5,6-Tetrafluoro-1,4-benzenedimethanol;92339-07-6;[2,3,5,6-tetrafluoro-4-(hydroxymethyl)phenyl]methanol;1,4-bis(hydroxymethyl)-2,3,5,6-tetrafluorobenzene;(perfluoro-1,4-phenylene)dimethanol;1,4-Benzenedimethanol, 2,3,5,6-tetrafluoro-;MFCD00229147;2,3,5,6-tetrafluoro-4-hydroxymethylphenylmethanol;SCHEMBL522934;DTXSID70399296;AKOS008901227;AC-8276;AS-15716;SY053052;(2,3,5,6-Tetrafluorophenylene)dimethanol;2,3,5,6-Tetrafluoro-1,4-dibenzylalkohol;AM20041414;CS-0043327;FT-0656798;T2732;2,3,5,6-Tetrafluoro-1,4-benzene dimethanol;D70650;EN300-173910;2, 3, 5, 6-Tetrafluoro-1, 4-benzenedimethanol;2,3,5,6-Tetrafluoro-p-xylene-alpha,alpha'-diol;A844202;2,3,5,6-Tetrafluoro-1,4-bis(hydroxymethyl)benzene;2,3,5,6-Tetrafluoro-alpha,alpha'-dihydroxy-p-xylene;(2,3,5,6-TETRAFLUORO-4-HYDROXYMETHYL-PHENYL)-METHANOL

Chemical Property of 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol

Chemical Property:

• Appearance/Colour: Light yellow crystal
• Vapor Pressure: 0.00815mmHg at 25°C
• Melting Point: 127.0 to 131.0 °C
• Refractive Index: 1.496
• Boiling Point: 255.979 °C at 760 mmHg
• PKA: 12.55±0.10(Predicted)
• Flash Point: 108.613 °C
• PSA: 40.46000
• Density: 1.569 g/cm³
• LogP: 1.22760
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 210.03039208
• Heavy Atom Count: 14
• Complexity: 156

Purity/Quality:

99% ^*data from raw suppliers

2,3,5,6-Tetrafluoro-1,4-benzenedimethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1=C(C(=C(C(=C1F)F)CO)F)F)O
• Use Description: 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol, a fluorinated compound, has several applications in different fields. In the field of organic chemistry, it serves as a valuable building block for the synthesis of various specialty chemicals, including pharmaceuticals and agrochemicals. Its fluorinated structure imparts unique properties to the molecules it is incorporated into, such as increased chemical stability and altered reactivity, making it valuable for drug discovery and crop protection. Additionally, in the field of materials science, this compound can be utilized as a monomer in the production of high-performance polymers and coatings, known for their exceptional resistance to heat, chemicals, and solvents. These materials find applications in the aerospace, automotive, and electronics industries, where durability and corrosion resistance are critical. Overall, 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol plays a pivotal role in both the development of specialized chemicals and the creation of advanced materials, with its unique fluorinated structure enhancing properties across multiple applications.

Technology Process of 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol

There total 43 articles about 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3,5,6-tetrafluoroterephthalic acid (652-36-8) → 2,3,5,6-tetrafluoro-1,4-benzenedimethanol (92339-07-6)

Guidance literature:

2,3,5,6-tetrafluoroterephthalic acid; With sodium tetrahydroborate; In 1,2-dimethoxyethane; at 20 - 70 ℃; for 8h;

With hydrogenchloride; water; In 1,2-dimethoxyethane; toluene; at 50 - 60 ℃; for 7h; Product distribution / selectivity;

Reference yield: 92.0%

dimethyl 2,3,5,6-tetrafluoroterephthalate (727-55-9) → 2,3,5,6-tetrafluoro-1,4-benzenedimethanol (92339-07-6)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In tetrahydrofuran; at 50 ℃; for 7h; Product distribution / selectivity;

Reference yield: 87.0%

magnesium sulfate anhydride + tert-butyl methyl ether (1634-04-4) + dimethyl 2,3,5,6-tetrafluoroterephthalate (727-55-9) → 2,3,5,6-tetrafluoro-1,4-benzenedimethanol (92339-07-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium borohydrid; In methanol; ethyl acetate; toluene;

upstream raw materials:

2,3,5,6-tetrafluoroterephthalaldehyde

tetrachloroterephthaloyl dichloride

tetrafluoroterephthalonitrile

2,3,5,6-tetrachloroterephthalonitrile

Downstream raw materials:

2,3,5,6-tetrafluoro-4-methylbenzyl alcohol

1,4-dimethyl-2,3,5,6-tetrafluorobenzene

4-chloromethyl-2,3,5,6-tetrafluorobenzyl alcohol

2,3,5,6-tetrafluoroterephthalaldehyde

Refernces

• 1、 -. "Synthesis method of 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol". Page/Page column 9-11. . Retrieved 2019/03/30.
• 2、 -. "Preparation method of 2,3,5,6-tetrafluorohydrazine-1,4-benzene dimethanol". Paragraph 0049; 0050. . Retrieved 2017/05/10.