Tetrahydro-2H-thiopyran-4-amine

Base Information

• Chemical Name: Tetrahydro-2H-thiopyran-4-amine
• CAS No.: 21926-00-1
• Molecular Formula: C5H11NS
• Molecular Weight: 117.215
• Hs Code.: 2934999090
• Mol file: 21926-00-1.mol

Synonyms:(Tetrahydrothiopyran-4-yl)amine;4-Aminotetrahydrothiopyran;NSC 106912;Tetrahydro-2H-thiopyran-4-amine;

Chemical Property of Tetrahydro-2H-thiopyran-4-amine

Chemical Property:

• Vapor Pressure: 0.478mmHg at 25°C
• Melting Point: 0°C
• Refractive Index: 1.524
• Boiling Point: 192.9 °C at 760 mmHg
• PKA: 9.59±0.20(Predicted)
• Flash Point: 70.5 °C
• PSA: 51.32000
• Density: 1.032g/cm³
• LogP: 1.54100

Purity/Quality:

98% ^*data from raw suppliers

Tetrahydrothiopyran-4-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): XiXn
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 20/21-36/37/39-26-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-2H-thiopyran-4-amine

There total 5 articles about Tetrahydro-2H-thiopyran-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tetrahydro-4H-thiopyran-4-one oxime (6309-59-7) → 4-tetrahydrothiopyranylamine (21926-00-1)

Guidance literature:

tetrahydro-4H-thiopyran-4-one oxime; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h; Heating / reflux;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

Tetrahydrothiopyran-4-one (1072-72-6) → 4-tetrahydrothiopyranylamine (21926-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / oximation

2: 81 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jo00335a011

Reference yield:

Tetrahydrothiopyran-4-one (1072-72-6) → 4-tetrahydrothiopyranylamine (21926-00-1) + N-(tetrahydro-2H-thiopyran-4-yl)tetrahydro-4H-thiopyran-4-imine

Guidance literature:

With ammonium hydroxide; nickel-aluminum alloy; water; at 20 ℃; for 2h; Sonication; Green chemistry;

DOI:10.1055/s-0035-1561647

upstream raw materials:

tetrahydro-4H-thiopyran-4-one oxime

Tetrahydrothiopyran-4-one

Downstream raw materials:

4-bromo-H-(tetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

4-(5-chloro-2-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

4-[2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide

Refernces

• 1、 Sch?fer, Christian,Ni?anci, Bilal,Bere, Matthew P.,Da?tan, Arif,T?r?k, Béla. "Heterogeneous Catalytic Reductive Amination of Carbonyl Compounds with Ni-Al Alloy in Water as Solvent and Hydrogen Source". . p. 3127 - 3133. Retrieved 2016/09/09.
• 2、 -. "1-(DIHYDRONAPHTHALENYL)PYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS". Page/Page column 59-60. . Retrieved 2013/10/22.