1-(2-Thiazolyl)piperazine dihydrochloride

Base Information

• Chemical Name: 1-(2-Thiazolyl)piperazine dihydrochloride
• CAS No.: 492431-13-7
• Molecular Formula: C₇H₁₁N₃S*2ClH
• Molecular Weight: 242.172
• Mol file: 492431-13-7.mol

Synonyms:Piperazine, 1-(2-thiazolyl)-, hydrochloride (1:2);1-(1,3-Thiazol-2-yl)piperazine dihydrochloride;

Chemical Property of 1-(2-Thiazolyl)piperazine dihydrochloride

Chemical Property:

• Vapor Pressure: 2.15E-05mmHg at 25°C
• Boiling Point: 355.7 °C at 760 mmHg
• Flash Point: 168.9 °C
• PSA: 56.40000
• LogP: 2.55050

Purity/Quality:

99.3% ^*data from raw suppliers

2-(Piperazin-1-yl)thiazoledihydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Thiazolyl)piperazine dihydrochloride

There total 1 articles about 1-(2-Thiazolyl)piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate (474417-23-7) → 1-(1,3-thiazol-2-yl)piperazine dihydrochloride (492431-13-7)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; dichloromethane; at 20 ℃; for 7h;

Reference yield:

(1S,2S)-4-oxo-2-(thiophene-3-yl)cyclohexanecarboxylic acid (1357456-73-5) + 2-(piperazin-1-yl)thiazole hydrochloride (209733-13-1,492431-13-7) → C27H34N4O2S2 (1357456-00-8) + C27H34N4O2S2

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: acetic acid / methanol; 1,2-dichloro-ethane / 20 - 55 °C

With benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2011.11.126

upstream raw materials:

tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate

Downstream raw materials:

C₂₇H₃₄N₄O₂S₂

Refernces