Z-PRO-GLY-NH2

Base Information

• Chemical Name: Z-PRO-GLY-NH2
• CAS No.: 35010-96-9
• Molecular Formula: C15H19N3O4
• Molecular Weight: 305.334
• Hs Code.: 2933990090
• Mol file: 35010-96-9.mol

Synonyms:1-Pyrrolidinecarboxylicacid, 2-[(carbamoylmethyl)carbamoyl]-, benzyl ester (7CI);Carbobenzoxy-L-prolylglycinamide;N-(Benzyloxycarbonyl)-L-prolylglycinamide;ZINC 04899833;

Chemical Property of Z-PRO-GLY-NH2

Chemical Property:

• Melting Point: 120 °C
• Boiling Point: 604.889 °C at 760 mmHg
• PKA: 14.49±0.20(Predicted)
• Flash Point: 319.626 °C
• PSA: 101.73000
• Density: 1.297 g/cm³
• LogP: 1.41820
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Z-Pro-Gly-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-PRO-GLY-NH2

There total 3 articles about Z-PRO-GLY-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

glycinamide hydrochloride (1668-10-6) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → Nα-benzyloxycarbonyl-L-prolyl-glycinamide (35010-96-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield: 94.0%

Z-Pro-Gly-OMe (61058-42-2) → Nα-benzyloxycarbonyl-L-prolyl-glycinamide (35010-96-9)

Guidance literature:

With ammonia; In methanol; for 24h; Ambient temperature;

DOI:10.1007/BF00571054

Reference yield:

N-benzyloxycarbonyl-L-proline p-nitrophenyl ester (3304-59-4) → Nα-benzyloxycarbonyl-L-prolyl-glycinamide (35010-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Ammonia, 2) 1,2,4-triazole / 1) Chloroform, 10 min, room temperature, 2) ethyl acetate, 1 h, room temperature.

2: 94 percent / Ammonia / methanol / 24 h / Ambient temperature

With 1,2,4-Triazole; ammonia; In methanol;

DOI:10.1007/BF00571054

upstream raw materials:

Z-Pro-Gly-OMe

glycinamide hydrochloride

N-Benzyloxycarbonyl-L-proline

N-benzyloxycarbonyl-L-proline p-nitrophenyl ester

Downstream raw materials:

N^α-Benzyloxycarbonyl-L-leucyl-L-arginyl-L-prolylglycine amide acetate sesquihydrate

Z-Pro-Gly-OMe

N-carbobenzoxyprolylglycine

{(S)-1-[(S)-1-{[((S)-1-{(S)-1-[(S)-2-(Carbamoylmethyl-carbamoyl)-pyrrolidine-1-carbonyl]-4-guanidino-butylcarbamoyl}-3-methyl-butylcarbamoyl)-methyl]-carbamoyl}-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-hydroxy-ethyl}-carbamic acid benzyl ester

Refernces

• 1、 Sutton,Clardy. "Synthesis and biological evaluation of analogues of the antibiotic pantocin B". . p. 9935 - 9946. Retrieved 2007/10/03.
• 2、 Nikolaev, S. V.,Martinov, V. F.. "Scheme for the synthesis of luliberin and analogs". . p. 269 - 270. Retrieved 2007/10/02.