7-CHLORO-8-METHYLQUINOLINE

Base Information

• Chemical Name: 7-CHLORO-8-METHYLQUINOLINE
• CAS No.: 78941-93-2
• Molecular Formula: C10H8ClN
• Molecular Weight: 177.633
• Hs Code.: 2933499090
• Mol file: 78941-93-2.mol

Synonyms:7-Chloro-8-methylquinoline;

Chemical Property of 7-CHLORO-8-METHYLQUINOLINE

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 45-48 °C
• Refractive Index: 1.635
• Boiling Point: 277.999 °C at 760 mmHg
• PKA: 3.47±0.31(Predicted)
• Flash Point: 157.512 °C
• PSA: 12.89000
• Density: 1.225 g/cm³
• LogP: 3.19660
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Chloro-8-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Chloro-8-methylquinoline (cas# 78941-93-2) is a compound useful in organic synthesis.

Technology Process of 7-CHLORO-8-METHYLQUINOLINE

There total 1 articles about 7-CHLORO-8-METHYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-8-methylquinoline (78941-95-4) → 8-methylquinoline (611-32-5) + 7-Chloro-8-methylquinoline (78941-93-2)

Guidance literature:

With chlorine; silver sulfate; In sulfuric acid; 1.)8 h 2.)r.t., 20 h;

DOI:10.1007/BF00505763

Reference yield: 93.0%

7-Chloro-8-methylquinoline (78941-93-2) + 1,2-dichloro-benzene (95-50-1) → 3,7-dichloro-8-chloromethyl quinoline (84086-96-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); chlorine;

Reference yield: 90.0%

7-Chloro-8-methylquinoline (78941-93-2) + N-phenyl-maleimide (941-69-5) → 3-((7-chloroquinolin-8-yl)methyl)-1-phenylpyrrolidine-2,5-dione

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; 1-Adamantanecarboxylic acid; In 1,2-dichloro-ethane; at 70 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.6b02295

upstream raw materials:

5-chloro-8-methylquinoline

Downstream raw materials:

7-Chloro-8-bromomethylquinoline

3,7-dichloro-8-dichloromethylquinoline

3,7-dichloro-8-chloromethyl quinoline

N-((7-chloroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide

Refernces