4-IODO-6-METHOXYQUINOLINE

Base Information

• Chemical Name: 4-IODO-6-METHOXYQUINOLINE
• CAS No.: 876492-00-1
• Molecular Formula: C₁₀H₈INO
• Molecular Weight: 285.084
• Mol file: 876492-00-1.mol

Synonyms:4-IODO-6-METHOXYQUINOLINE

Chemical Property of 4-IODO-6-METHOXYQUINOLINE

Chemical Property:

• Vapor Pressure: 4.77E-05mmHg at 25°C
• Melting Point: 85 °C
• Refractive Index: 1.683
• Boiling Point: 359.9 °C at 760 mmHg
• PKA: 3.62±0.16(Predicted)
• Flash Point: 171.5 °C
• PSA: 22.12000
• Density: 1.75 g/cm³
• LogP: 2.84800

Purity/Quality:

98.5% ^*data from raw suppliers

4-Iodo-6-methoxyquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODO-6-METHOXYQUINOLINE

There total 4 articles about 4-IODO-6-METHOXYQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-bromo-6-methoxyquinoline (42881-66-3) → 4-iodo-6-methoxyquinoline (876492-00-1)

Guidance literature:

With acetic anhydride; sodium iodide; In acetonitrile; at 18 - 80 ℃; Microwave irradiation;

DOI:10.1021/jo9008386

Reference yield: 93.0%

6-methoxyquinolin-4-yl trifluoromethanesulfonate (282547-45-9) → 4-iodo-6-methoxyquinoline (876492-00-1)

Guidance literature:

With acetic anhydride; sodium iodide; In acetonitrile; at 18 - 80 ℃; Microwave irradiation;

DOI:10.1021/jo9008386

Reference yield: 92.0%

6-methoxyquinolin-4-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate (1161941-02-1) → 4-iodo-6-methoxyquinoline (876492-00-1)

Guidance literature:

With acetic anhydride; sodium iodide; In acetonitrile; at 18 - 80 ℃; Microwave irradiation;

DOI:10.1021/jo9008386

upstream raw materials:

6-methoxy-4-aminoquinoline

6-methoxyquinolin-4-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

6-methoxyquinolin-4-yl trifluoromethanesulfonate

4-bromo-6-methoxyquinoline

Refernces