t-Butyldimethylsilyl

Base Information

• Chemical Name: t-Butyldimethylsilyl
• CAS No.: 29681-57-0
• Molecular Formula: C6H16Si
• Molecular Weight: 116.279
• Hs Code.: 29319090
• European Community (EC) Number: 627-972-4
• Mol file: 29681-57-0.mol

Synonyms:tBDMCS;tert-butyldimethylsilane

Chemical Property of t-Butyldimethylsilyl

Chemical Property:

• Melting Point: 13°C
• Refractive Index: n20/D 1.4(lit.)
• Boiling Point: 82.697 °C at 760 mmHg
• Flash Point: -22.778 °C
• PSA: 0.00000
• Density: 0.701 g/mL at 25 °C(lit.)
• LogP: 2.27320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 115.094302013
• Heavy Atom Count: 7
• Complexity: 49.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyldimethylsilane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, Xi
• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36-16/26/36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)C

Technology Process of t-Butyldimethylsilyl

There total 3 articles about t-Butyldimethylsilyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl(cyclohex-1-en-1-yloxy)dimethylsilane (62791-22-4) → tert-butyldimethylsilane (29681-57-0) + <2-D>Cyclohexanone (2979-36-4)

Guidance literature:

With deuterium; [RuCl(η²-H2)(dppe)2]OTf; In 1,2-dichloro-ethane; at 50 ℃; for 48h; under 760 Torr;

DOI:10.1016/S0022-328X(03)00470-4

Reference yield:

Zn(Si(CH3)2(C(CH3)3))2 (1380397-69-2) → tert-butyldimethylsilane (29681-57-0) + 1,2-di-tert-butyl-1,1,2,2-tetramethyldisilane (63262-93-1)

Guidance literature:

With [(1,2-bis(dimethylphosphanyl)ethane)Pt(PEt₃)₂]; In hexane; at 80 ℃; for 2.5h; Schlenk technique;

DOI:10.1002/anie.201505805

Reference yield:

(tBuMe2Si)2Hg → tert-butyldimethylsilane (29681-57-0) + 1,2-di-tert-butyl-1,1,2,2-tetramethyldisilane (63262-93-1)

Guidance literature:

With [(1,2-bis(dimethylphosphanyl)ethane)Pt(PEt₃)₂]; In hexane; at 60 ℃; for 2.5h; Schlenk technique;

DOI:10.1002/anie.201505805

upstream raw materials:

tert-butyl(cyclohex-1-en-1-yloxy)dimethylsilane

Zn(Si(CH₃)2(C(CH₃)3))2

Downstream raw materials:

tert-butyl((4-methoxybenzyl)oxy)dimethylsilane

ethyl 2-(tert-butyldimethylsilyl)propanoate

N-(((tert-butyldimethylsilyl)oxy)carbonyl)phenylalanine methyl ester

1-(tert-Butyl-dimethyl-silanyl)-1-phenyl-ethane-1,2-diol

Refernces

• 1、 Takei, Izuru,Nishibayashi, Yoshiaki,Ishii, Youichi,Mizobe, Yasushi,Uemura, Sakae,Hidai, Masanobu. "Novel catalytic hydrogenolysis of silyl enol ethers by the use of acidic ruthenium dihydrogen complexes". . p. 32 - 42. Retrieved 2007/10/03.