5-Pyrimidinemethanamine

Base Information

• Chemical Name: 5-Pyrimidinemethanamine
• CAS No.: 25198-95-2
• Molecular Formula: C₅H₇N₃
• Molecular Weight: 109.131
• Hs Code.: 29335990
• Mol file: 25198-95-2.mol

Synonyms:Pyrimidine,5-(aminomethyl)- (8CI);(Pyrimidin-5-ylmethyl)amine;

Chemical Property of 5-Pyrimidinemethanamine

Chemical Property:

• Appearance/Colour: Low-melting yellow solid
• Vapor Pressure: 0.0918mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 224.3 °C at 760 mmHg
• PKA: 7.89±0.29(Predicted)
• Flash Point: 112.1 °C
• PSA: 51.80000
• Density: 1.138 g/cm³
• LogP: 0.63560
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

5-Pyrimidinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Pyrimidinemethanamine (cas# 25198-95-2) is a compound useful in organic synthesis.

Technology Process of 5-Pyrimidinemethanamine

There total 4 articles about 5-Pyrimidinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

5-pyrimidinylmethyl chloride (101346-02-5) → (pyrimidin‐5‐yl)methanamine (25198-95-2)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

5-(azidomethyl)pyrimidine → (pyrimidin‐5‐yl)methanamine (25198-95-2)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 25 ℃; for 16h;

Reference yield:

5-(hydroxymethyl)pyrimidine (25193-95-7) → (pyrimidin‐5‐yl)methanamine (25198-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / dichloromethane; toluene / 16 h / 25 °C

2: triphenylphosphine / water; tetrahydrofuran / 16 h / 25 °C

With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; toluene;

upstream raw materials:

5-(hydroxymethyl)pyrimidine

pyrimidine-5-carbaldehyde

5-pyrimidinylmethyl chloride

Downstream raw materials:

C₁₈H₁₆N₄O₃S

C₂₁H₁₉N₅O

C₁₅H₁₄N₂

C₁₈H₁₅N₃

Refernces

• 1、 -. "SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN". . . Retrieved 2016/06/06.