Technology Process of (5-amino-2-trifluoromethyl-phenyl)-(4-ethyl-piperazin-1-yl)-methanone
There total 3 articles about (5-amino-2-trifluoromethyl-phenyl)-(4-ethyl-piperazin-1-yl)-methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
5%-palladium/activated carbon; ammonium formate;
In
methanol;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: chromium(VI) oxide; sulfuric acid; acetic acid / water / 1 h / Reflux
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / 2 h / 20 °C
3: 5%-palladium/activated carbon; ammonium formate / methanol / 3 h / Reflux
With
chromium(VI) oxide; sulfuric acid; 5%-palladium/activated carbon; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / 2 h / 20 °C
2: 5%-palladium/activated carbon; ammonium formate / methanol / 3 h / Reflux
With
5%-palladium/activated carbon; ammonium formate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
methanol;