2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL

Base Information

• Chemical Name: 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL
• CAS No.: 4677-18-3
• Molecular Formula: C7H14O2
• Molecular Weight: 130.187
• Hs Code.: 2932999099
• Mol file: 4677-18-3.mol

Synonyms:Pyran-4-ethanol,tetrahydro- (6CI,7CI,8CI);2-(Tetrahydro-2H-pyran-4-yl)ethanol;2-(Tetrahydropyran-4-yl)ethanol;4-(2-Hydroxyethyl)tetrahydropyran;(4-Hydroxyethyl)tetrahydropyran;

Chemical Property of 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.449
• Boiling Point: 226.048 °C at 760 mmHg
• PKA: 15.06±0.10(Predicted)
• Flash Point: 95.435 °C
• PSA: 29.46000
• Density: 0.982 g/cm³
• LogP: 0.79540
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-(Oxan-4-yl)ethan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-21/22-36/37/38-41-37/38
• Safety Statements: 16-23-26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL

There total 7 articles about 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl tetrahydropyran-4-acetate (103260-44-2) → 2-(tetrahydropyran-4-yl)-ethanol (4677-18-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1021/jo061977a

Reference yield: 95.0%

2-(tetrahydro-2H-pyran-4-yl)acetic acid (85064-61-5) → 2-(tetrahydropyran-4-yl)-ethanol (4677-18-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00862

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → 2-(tetrahydropyran-4-yl)-ethanol (4677-18-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / benzene / 0.5 h / 20 °C

1.2: 92 percent / benzene / 1 h / 60 °C

2.1: 98.5 percent / hydrogen / Pd/C / ethanol / 2585.74 Torr

3.1: 100 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; benzene;

DOI:10.1021/jo061977a

upstream raw materials:

ethyl tetrahydropyran-4-acetate

3-carboxymethylglutaric acid

Tetrahydro-4H-pyran-4-one

ethyl tetrahydro-4H-pyran-4-ylideneacetate

Downstream raw materials:

2-(tetrahydro-2H-pyran-4-yl)acetaldehyde

2-(tetrahydro-2H-pyran-4-yl)ethyl 4-methylbenzenesulfonate

C₄₀H₄₄F₄N₄O₆S

Quinuclidine

Refernces

• 1、 -. "Dihydropyrrolopyridine inhibitors of ROR-gamma". Page/Page column 31; 32. . Retrieved 2016/11/21.
• 2、 -. "DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA". Paragraph 00106. . Retrieved 2016/05/24.