1H-Benzimidazole-5-methanamine(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole-5-methanamine(9CI)
• CAS No.: 164648-60-6
• Molecular Formula: C8H9N3
• Molecular Weight: 147.18
• Hs Code.: 2933990090
• Mol file: 164648-60-6.mol

Synonyms:1H-Benzimidazole-5-methanamine(9CI);(1H-Benzimidazol-5-yl)methanamine;5-Aminomethylbenzimidazole;

Chemical Property of 1H-Benzimidazole-5-methanamine(9CI)

Chemical Property:

• Boiling Point: 432.844 °C at 760 mmHg
• PKA: 12.79±0.10(Predicted)
• Flash Point: 245.506 °C
• PSA: 54.70000
• Density: 1.279 g/cm³
• LogP: 1.72190

Purity/Quality:

98%min ^*data from raw suppliers

(1H-Benzo[d]imidazol-5-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-5-methanamine(9CI)

There total 3 articles about 1H-Benzimidazole-5-methanamine(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(1H-benzo[d]imidazol-6-yl)methanol (106429-29-2) → 1H-1,3-benzodiazol-6-ylmethanamine (164648-60-6)

Guidance literature:

(1H-benzo[d]imidazol-6-yl)methanol; With diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 4h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 96h;

Reference yield:

6-azidomethyl-1H-benzo [d]imidazole (267875-43-4) → 1H-1,3-benzodiazol-6-ylmethanamine (164648-60-6)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

Reference yield:

5-benzimidazolecarboxylic acid (15788-16-6) → 1H-1,3-benzodiazol-6-ylmethanamine (164648-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 96 h / 0 - 20 °C

2.1: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / 20 °C

2.2: 96 h / 20 °C

With lithium aluminium tetrahydride; diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

upstream raw materials:

6-azidomethyl-1H-benzo [d]imidazole

5-benzimidazolecarboxylic acid

(1H-benzo[d]imidazol-6-yl)methanol

Downstream raw materials:

N-(1H-1,3-benzodiazol-6-ylmethyl)-4-(4-fluorophenoxy)piperidine-1-carboxamide

Refernces

• 1、 -. "NOVEL JNK INHIBITORS". Page/Page column 97; 98. . Retrieved 2008/12/07.