Technology Process of 4-chloro-N-[(4-cyanophenyl)thiocarbamoyl]deacetyl colchicine
There total 5 articles about 4-chloro-N-[(4-cyanophenyl)thiocarbamoyl]deacetyl colchicine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
thiophosgene; 4-Aminobenzonitrile;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 2h;
Inert atmosphere;
4-Chlorodeacetylcolchicine;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1039/c3md00287j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium methylate / methanol / 6 h / 20 °C
2.1: trifluoroacetic acid / 0.33 h / 20 °C
3.1: triethylamine / dichloromethane / 2 h / Cooling with ice; Inert atmosphere
3.2: 20 °C
With
sodium methylate; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; N-chloro-succinimide / 3 h / 70 °C / Inert atmosphere
2.1: triethylamine; dmap / acetonitrile / 10.5 h / 100 °C / Reflux
3.1: sodium methylate / methanol / 6 h / 20 °C
4.1: trifluoroacetic acid / 0.33 h / 20 °C
5.1: triethylamine / dichloromethane / 2 h / Cooling with ice; Inert atmosphere
5.2: 20 °C
With
dmap; N-chloro-succinimide; sodium methylate; acetic acid; triethylamine; trifluoroacetic acid;
In
methanol; dichloromethane; acetonitrile;
