(R)-3-Piperidinamine dihydrochloride

Base Information

• Chemical Name: (R)-3-Piperidinamine dihydrochloride
• CAS No.: 334618-23-4
• Molecular Formula: C₅H₁₂N₂*ClH
• Molecular Weight: 136.625
• Hs Code.: 29339900
• Mol file: 334618-23-4.mol

Synonyms:3-Piperidinamine,dihydrochloride, (3R)- (9CI);(R)-(-)-3-Aminopiperidine dihydrochloride;

Chemical Property of (R)-3-Piperidinamine dihydrochloride

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 190-195 °C
• Boiling Point: 241.9 °C at 760 mmHg
• Flash Point: 100.1 °C
• PSA: 38.05000
• LogP: 2.33020
• Storage Temp.: Room temperature.
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

≥98.0% ^*data from raw suppliers

(R)-(-)-3-Aminopiperidine Dihydrochloride >97.0%(N)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-39-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical structure: (R)-3-Aminopiperidine dihydrochloride is a chiral compound with a piperidine ring structure and two hydrochloride ions.
• Uses: Used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin. Key chiral intermediate in the synthesis of drugs for the treatment of type II diabetes, such as linagliptin and alogliptin.
• Production Methods: Chemical synthesis method involves the reaction of (R)-1-Boc-3-aminopiperidine with acetyl chloride to yield (R)-3-aminopiperidine dihydrochloride. The synthesis method involves several steps including salt formation, reduction, Hofmann degradation, chiral resolution, and hydrogenation.

Technology Process of (R)-3-Piperidinamine dihydrochloride

There total 77 articles about (R)-3-Piperidinamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3R)-1-benzyl-3-aminopiperidine (168466-84-0) → 3-(R)-aminopiperidine dihydrochloride (334618-23-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; at 40 ℃; for 24h;

Reference yield: 99.0%

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3,172603-05-3) → 3-(R)-aminopiperidine dihydrochloride (334618-23-4)

Guidance literature:

With hydrogenchloride; In tert-butyl methyl ether; at 0 - 20 ℃; for 8h;

Reference yield: 96.5%

nipecotamide (4138-26-5,168749-30-2) → 3-amino-piperidine dihydrochloride (127294-75-1,138060-07-8,150395-91-8,334618-23-4)

Guidance literature:

nipecotamide; With tetrafluoroboric acid; 1-Fluoronaphthalene; dihydrogen peroxide;

With hydrogenchloride; In ethanol; water; for 0.5h;

upstream raw materials:

pyridin-3-ylamine

N-acetyl-3-aminopyridine acetate

N-acetyl-3-aminopiperidine acetate

nipecotamide

Downstream raw materials:

(S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

Refernces

• 1、 -. "Synthesis method of trelagliptin intermediate". Paragraph 0020; 0090-0097. . Retrieved 2021/07/17.
• 2、 -. "Synthetic process of anti-hyperglycemic drug intermediate R-3-amino-piperidine dihydrochloride". . . Retrieved 2019/11/12.