2-methyl-3,3-diphenylpropanenitrile

Base Information

• Chemical Name: 2-methyl-3,3-diphenylpropanenitrile
• CAS No.: 22101-23-1
• Molecular Formula: C₁₆H₁₃N
• Molecular Weight: 219.286
• Mol file: 22101-23-1.mol

Synonyms:2-methyl-3,3-diphenylpropanenitrile

Chemical Property of 2-methyl-3,3-diphenylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3,3-diphenylpropanenitrile

There total 7 articles about 2-methyl-3,3-diphenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-hydroxy-2-methyl-3,3-diphenyl-propionitrile (6275-86-1) → 2-methyl-3,3-diphenylpropanenitrile (22101-23-1)

Guidance literature:

With formic acid; for 0.5h; Heating;

DOI:10.1016/0223-5234(92)90145-Q

Reference yield: 79.0%

1,1-diphenyl-1-propene (778-66-5) + trimethylsilyl cyanide (7677-24-9) → 2-methyl-3,3-diphenylpropanenitrile (22101-23-1)

Guidance literature:

trimethylsilyl cyanide; With (3,5-bis(trifluoromethyl)phenyl)-λ³-iodanediyl bis(2,2,2-trifluoroacetate); trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 0.0166667h; Inert atmosphere; Schlenk technique;

1,1-diphenyl-1-propene; In 1,2-dichloro-ethane; at 40 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201807303

Reference yield: 2.0%

9-fluorenone (486-25-9,952573-42-1) + acetonitrile (75-05-8,26809-02-9) → 2-methyl-3,3-diphenylpropanenitrile (22101-23-1) + (E)-1-(9'-fluorenylidene)-2-cyano-3-amino-2-butene (83026-87-3)

Guidance literature:

With Azobenzene; Yield given. Multistep reaction; 1.) electrolyse, 2.) 3 h;

DOI:10.1021/jo00144a039

upstream raw materials:

3-hydroxy-2-methyl-3,3-diphenyl-propionitrile

benzophenone

acetonitrile

9-fluorenone

Downstream raw materials:

2-methyl-3,3-diphenyl-2-propen-1-amine

Refernces

• 1、 Wang, Xi,Studer, Armido. "Metal-Free Direct C?H Cyanation of Alkenes". supporting information. p. 11792 - 11796. Retrieved 2018/09/10.
• 2、 Blank,Zuccarello,Cohen,Frishmuth,Scaricaciottoli. "Synthesis and adrenocortical inhibiting activity of substituted diphenylalkylamines.". . p. 271 - 276. Retrieved 2007/10/05.