7-BROMO-1H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 7-BROMO-1H-QUINAZOLIN-4-ONE
• CAS No.: 194851-16-6
• Molecular Formula: C8H5BrN2O
• Molecular Weight: 225.044
• Hs Code.: 2933990090
• Mol file: 194851-16-6.mol

Synonyms:4(1H)-Quinazolinone,7-bromo- (9CI);7-Bromo-3,4-dihydroquinazolin-4-one;7-Bromo-3H-quinazolin-4-one;7-Bromo-1H-quinazolin-4-one;

Chemical Property of 7-BROMO-1H-QUINAZOLIN-4-ONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.721
• Boiling Point: 428.784 °C at 760 mmHg
• PKA: 0.36±0.20(Predicted)
• Flash Point: 213.121 °C
• PSA: 45.75000
• Density: 1.822 g/cm³
• LogP: 1.68560
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

7-Bromoquinazolin-4-ol ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of 7-BROMO-1H-QUINAZOLIN-4-ONE

There total 19 articles about 7-BROMO-1H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (E)-4-bromo-2-(((dimethylamino)methylene)amino)benzoate (1427534-38-0) + formamide (77287-34-4,77287-35-5,60100-09-6) → 7-bromoquinazolin-4-one (194851-16-6)

Guidance literature:

With indium(III) chloride; at 200 ℃; for 0.583333h; Microwave irradiation;

DOI:10.1016/j.tet.2013.02.066

Reference yield: 100.0%

2-amino-4-bromo-benzoic acid methyl ester (135484-83-2) + formamide (77287-34-4,77287-35-5,60100-09-6) → 7-bromoquinazolin-4-one (194851-16-6)

Guidance literature:

With indium(III) chloride; at 200 ℃; for 0.583333h; Microwave irradiation;

DOI:10.1016/j.tet.2013.02.066

Reference yield: 98.0%

2-amino-4-bromobenzoic acid (20776-50-5) + formamidine acetic acid (3473-63-0) → 7-bromoquinazolin-4(3H)-one (194851-16-6)

Guidance literature:

In 2-ethoxy-ethanol; for 13h; Heating / reflux;

upstream raw materials:

2-amino-4-bromobenzoic acid

formamide

2-amino-4-bromobenzamide

orthoformic acid triethyl ester

Downstream raw materials:

C₂₁H₁₆F₂N₆O₂S

3-benzyl-7-bromo-6-nitroquinazolin-4(3H)-one

6-amino-3-benzyl-7-bromoquinazolin-4(3H)-one

3-benzyl-7-bromo-6-[(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]quinazolin-4(3H)-one

Refernces

• 1、 Sun, Bin,Ding, Hao,Tian, Hai-Xia,Huang, Pan-Yi,Jin, Can,Wu, Chun-Lei,Shen, Run-Pu. "Photo-Triggered Self-Induced Homolytic Dechlorinative Sulfonylation/Cyclization of Unactivated Alkenes: Synthesis of Quinazolinones Containing a Sulfonyl Group". supporting information. p. 766 - 772. Retrieved 2021/12/22.
• 2、 Dung, Do T. M.,Park, Eun J.,Anh, Duong T.,Hai, Pham-The,Huy, Le D.,Jun, Hye W.,Kwon, Joo-Hee,Young Ji,Kang, Jong S.,Tung, Truong T.,Dung, Phan T. P.,Han, Sang-Bae,Nam, Nguyen-Hai. "Design, synthesis, and evaluation of novel (E)-N'-(3-allyl-2-hydroxy)benzylidene-2-(4-oxoquinazolin-3(4H)-yl)acetohydrazides as antitumor agents". . . Retrieved 2021/10/25.