3-(4-Hydroxy-2,3-Dimethyl-Phenyl)-Propionic Acid Ethyl Ester

Base Information

• Chemical Name: 3-(4-Hydroxy-2,3-Dimethyl-Phenyl)-Propionic Acid Ethyl Ester
• CAS No.: 1234845-57-8
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.284
• Mol file: 1234845-57-8.mol

Synonyms:3-(4-hydroxy-2,3-dimethylphenyl)propionic acid ethyl ester

Chemical Property of 3-(4-Hydroxy-2,3-Dimethyl-Phenyl)-Propionic Acid Ethyl Ester

Chemical Property:

Purity/Quality:

Ethyl3-(2,3-Dimethyl-4-hydroxyphenyl)propanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Hydroxy-2,3-Dimethyl-Phenyl)-Propionic Acid Ethyl Ester

There total 4 articles about 3-(4-Hydroxy-2,3-Dimethyl-Phenyl)-Propionic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

→ 3-(4-hydroxy-2,3-dimethylphenyl)propionic acid ethyl ester (1234845-57-8)

Guidance literature:

Reference yield:

2,3-Dimethyl-4-hydroxybenzaldehyde (58380-40-8) → 3-(4-hydroxy-2,3-dimethylphenyl)propionic acid ethyl ester (1234845-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2017.01.034

Reference yield:

C13H16O3 → 3-(4-hydroxy-2,3-dimethylphenyl)propionic acid ethyl ester (1234845-57-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2017.01.034

upstream raw materials:

2,3-Dimethyl-4-hydroxybenzaldehyde

2,3-dimethyl-4-hydroxybenzonitrile

Refernces

• 1、 -. "THIOARYL DERIVATIVES AS GPR120 AGONISTS". Paragraph 867-869. . Retrieved 2014/05/24.
• 2、 -. "GPR120 RECEPTOR AGONISTS AND USES THEREOF". Page/Page column 39. . Retrieved 2012/01/13.