5,6-DIHYDRO-4H-4-HYDROXY-6-METHYLTHIENO[2,3-B]THIOPYRAN-2-SULPHONAMIDE

Base Information

• Chemical Name: 5,6-DIHYDRO-4H-4-HYDROXY-6-METHYLTHIENO[2,3-B]THIOPYRAN-2-SULPHONAMIDE
• CAS No.: 120298-37-5
• Molecular Formula: C₈H₁₁NO₃S₃
• Molecular Weight: 265.378
• Hs Code.: 2935009090
• Mol file: 120298-37-5.mol

Synonyms:5,6-DIHYDRO-4H-4-HYDROXY-6-METHYLTHIENO[2,3-B]THIOPYRAN-2-SULPHONAMIDE

Chemical Property of 5,6-DIHYDRO-4H-4-HYDROXY-6-METHYLTHIENO[2,3-B]THIOPYRAN-2-SULPHONAMIDE

Chemical Property:

• PSA: 142.31000
• LogP: 3.09430

Purity/Quality:

99%, ^*data from raw suppliers

5,6-DIHYDRO-4H-4-HYDROXY-6-METHYLTHIENO-[2,3-B]THIOPYRAN-2-SULPHONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DIHYDRO-4H-4-HYDROXY-6-METHYLTHIENO[2,3-B]THIOPYRAN-2-SULPHONAMIDE

There total 1 articles about 5,6-DIHYDRO-4H-4-HYDROXY-6-METHYLTHIENO[2,3-B]THIOPYRAN-2-SULPHONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5,6-dihydro-6-methyl-4-oxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide → 5,6-Dihydro-4H-4-hydroxy-6-methylthieno[2,3-b]thiopyran-2-sulfonamide (120298-37-5)

Guidance literature:

5,6-dihydro-6-methyl-4-oxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide; With sodium tetrahydroborate; In methanol; at 25 - 30 ℃; for 2h;

With water; acetic acid; at 20 - 25 ℃; for 1.5h; pH=6.5 - 7;

Reference yield: 76.72%

5,6-Dihydro-4H-4-hydroxy-6-methylthieno[2,3-b]thiopyran-2-sulfonamide (120298-37-5) → 5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide (154802-22-9)

Guidance literature:

With sodium perborate; acetic acid; at 25 - 65 ℃; for 4h;

Downstream raw materials:

5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide

Refernces

• 1、 -. "PROCESS FOR PREPARING DORZOLAM IDE". Page/Page column 17-18. . Retrieved 2009/01/20.
• 2、 -. "PROCESS FOR PREPARING 5,6-DIHYDRO-4-(S)-(ETHYLAMINO)-6-(S) METHYL-4H-THIENO[2,3b]THIOPYRAN-2-SULPHONAMIDE-7,7-DIOXIDE HCI". Page/Page column 7; 9; 12-13. . Retrieved 2008/06/13.