3-(6-CHLORO-PYRIDAZIN-3-YL-AMINO)-PROPIONIC ACID

Base Information

• Chemical Name: 3-(6-CHLORO-PYRIDAZIN-3-YL-AMINO)-PROPIONIC ACID
• CAS No.: 27255-10-3
• Molecular Formula: C7H8ClN3O2
• Molecular Weight: 201.6103
• Hs Code.: 2933990090
• Mol file: 27255-10-3.mol

Synonyms:N-(6-Chloropyridazin-3-yl)-β-alanine;3-[(6-Chloropyridazin-3-yl)amino]propanoic acid;

Chemical Property of 3-(6-CHLORO-PYRIDAZIN-3-YL-AMINO)-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 1.73E-12mmHg at 25°C
• Melting Point: 217-218 °C (decomp)
• Refractive Index: 1.626
• Boiling Point: 539.9 °C at 760 mmHg
• PKA: 4.36±0.10(Predicted)
• Flash Point: 280.3 °C
• PSA: 75.11000
• Density: 1.494 g/cm³
• LogP: 1.08960

Purity/Quality:

99% ^*data from raw suppliers

3-[(6-Chloropyridazin-3-yl)amino]propanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(6-CHLORO-PYRIDAZIN-3-YL-AMINO)-PROPIONIC ACID

There total 1 articles about 3-(6-CHLORO-PYRIDAZIN-3-YL-AMINO)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3,6-dichlorpyridazine (141-30-0) + 3-amino propanoic acid (107-95-9) → N-(3-chloropyridazin-6-yl)-3-aminopropionic acid (27255-10-3)

Guidance literature:

With potassium carbonate; In ethanol; Heating;

DOI:10.1021/ja9717424

Reference yield: 57.0%

N-(3-chloropyridazin-6-yl)-3-aminopropionic acid (27255-10-3) + benzyl alcohol (100-51-6,185532-71-2) → N-(3-benzyloxypyridazin-6-yl)-3-aminopropionic acid (200184-26-5)

Guidance literature:

With sodium hydride; at 165 ℃; for 3h;

DOI:10.1021/ja9717424

Reference yield: 48.0%

4-Methoxybenzyl alcohol (105-13-5) + N-(3-chloropyridazin-6-yl)-3-aminopropionic acid (27255-10-3) → C15H17N3O4

Guidance literature:

4-Methoxybenzyl alcohol; With sodium hydride; In mineral oil; at 80 ℃;

N-(3-chloropyridazin-6-yl)-3-aminopropionic acid; In mineral oil; at 160 ℃; for 1h;

DOI:10.1002/cbic.201900393

upstream raw materials:

3,6-dichlorpyridazine

3-amino propanoic acid

Downstream raw materials:

N-(3-benzyloxypyridazin-6-yl)-3-aminopropionic acid

Ethyl N-(2-Boc-aminoethyl)-N-[N'-{(3-benzyloxy)pyridazine-6-yl}-3-aminopropionyl]glycinate

Refernces

• 1、 -. "Peptide nucleic acid monomers and oligomers". . . Retrieved 2008/06/13.