3-CHLORO-6-(3-CHLOROPHENYL)-PYRIDAZINE

Base Information

• Chemical Name: 3-CHLORO-6-(3-CHLOROPHENYL)-PYRIDAZINE
• CAS No.: 66548-94-5
• Molecular Formula: C10H6Cl2N2
• Molecular Weight: 225.077
• Hs Code.: 2933990090
• Mol file: 66548-94-5.mol

Synonyms:3-CHLORO-6-(3-CHLOROPHENYL)-PYRIDAZINE;1-Chloro-3-(6-chloropyridazin-3-yl)benzene, 3-Chloro-6-(3-chlorophenyl)-1,2-diazine

Chemical Property of 3-CHLORO-6-(3-CHLOROPHENYL)-PYRIDAZINE

Chemical Property:

• Vapor Pressure: 2.09E-06mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 405.2 °C at 760 mmHg
• PKA: 0.12±0.10(Predicted)
• Flash Point: 231.2 °C
• PSA: 25.78000
• Density: 1.363 g/cm³
• LogP: 3.45040

Purity/Quality:

99%min ^*data from raw suppliers

3-Chloro-6-(3-chlorophenyl)pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-6-(3-CHLOROPHENYL)-PYRIDAZINE

There total 2 articles about 3-CHLORO-6-(3-CHLOROPHENYL)-PYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichlorpyridazine (141-30-0) + 3-chlorophenylboronic acid (63503-60-6) → 3-chloro-6-(meta-chlorophenyl)pyridazine (66548-94-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 90 - 110 ℃; for 5h;

Reference yield:

→ 3-chloro-6-(meta-chlorophenyl)pyridazine (66548-94-5)

Guidance literature:

Reference yield: 88.0%

3-chloro-6-(meta-chlorophenyl)pyridazine (66548-94-5) → 6-(3-chlorophenyl)-2,3-dihydropyridazin-3-one (62902-66-3)

Guidance literature:

With acetic acid; at 120 ℃; for 4h;

DOI:10.1016/j.bmcl.2014.08.067

upstream raw materials:

3,6-dichlorpyridazine

3-chlorophenylboronic acid

Downstream raw materials:

3-(4-hydroxypiperidino)-6-(3-chlorophenyl)pyridazine

6-(3-chloro-phenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine

6-(m-chlorophenyl)-1,2,4-triazolo[4,3-b]pyridazine

Methyl-carbamic acid 1-[6-(3-chloro-phenyl)-pyridazin-3-yl]-piperidin-4-yl ester

Refernces

• 1、 -. "6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents". . . Retrieved 2008/06/13.