Magnesium bromide 3,5-difluorobenzen-1-ide (1/1/1)

Base Information

• Chemical Name: Magnesium bromide 3,5-difluorobenzen-1-ide (1/1/1)
• CAS No.: 62351-47-7
• Molecular Formula: C6H3BrF2Mg
• Molecular Weight: 217.296
• Hs Code.: 29319090
• DSSTox Substance ID: DTXSID90380888
• Mol file: 62351-47-7.mol

Synonyms:Magnesium bromide 3,5-difluorobenzen-1-ide (1/1/1);magnesium;1,3-difluorobenzene-5-ide;bromide;DTXSID90380888

Chemical Property of Magnesium bromide 3,5-difluorobenzen-1-ide (1/1/1)

Chemical Property:

• Vapor Pressure: 82.7mmHg at 25°C
• Boiling Point: 65 °C
• Flash Point: <1 °F
• PSA: 0.00000
• Density: 0.971 g/mL at 25 °C
• LogP: 2.61060
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 215.92366
• Heavy Atom Count: 10
• Complexity: 156

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Difluorophenylmagnesium bromide solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, C
• Hazard Codes: F,C,Xn
• Statements: 11-14-19-22-34-36/37-40
• Safety Statements: 16-26-33-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=[C-]C=C(C=C1F)F.[Mg+2].[Br-]
• Uses: 3,5-Difluorophenylmagnesium bromide can be used:As a starting material in the synthesis of cis-2-phenyl-1-amino-cyclopentanes as AMPA receptor potentiators.To prepare copper(I) complexes, which are used as luminescent guest molecules in organic light-emitting diodes (OLEDs).As an intermediate in the synthesis of 2-aminoethylbenzofuran H3 receptor antagonists.

Technology Process of Magnesium bromide 3,5-difluorobenzen-1-ide (1/1/1)

There total 1 articles about Magnesium bromide 3,5-difluorobenzen-1-ide (1/1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-difluorobromobenzene (461-96-1) → 3,5-difluorophenylmagnesium bromide (62351-47-7)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield: 100.0%

3,5-difluorophenylmagnesium bromide (62351-47-7) + (S)-2-(dibenzylamino)propanal (120205-96-1,121010-18-2,129286-74-4,111060-63-0) → C23H23F2NO (1227306-82-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 0.5h;

DOI:10.1021/acs.jmedchem.0c00446

Reference yield: 90.0%

Cyclopentene oxide (285-67-6) + 3,5-difluorophenylmagnesium bromide (62351-47-7) → (1S,2R)-2-(3,5-difluorophenyl)cyclopentanol (1263869-50-6)

Guidance literature:

Cyclopentene oxide; 3,5-difluorophenylmagnesium bromide; copper(l) iodide; In tetrahydrofuran; at 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;

upstream raw materials:

3,5-difluorobromobenzene

Downstream raw materials:

bis(3,5-difluorophenyl)phosphine oxide

4-(1-(3',5'-difluorophenyl)-1-hydroxymethyl)-1,2-dimethoxy-5-(4-methylthiophenyl)benzene

(3,5-difluorophenyl)(6-(4-methylthiophenyl)(2H-benzo[d]1,3-dioxolan-5-yl))methan-1-ol

1-allyl-3,5-difluorobenzene

Refernces

• 1、 -. "2-fluorobenzonitrile derivative". . . Retrieved 2008/06/13.