Magnesium bromide 3,5-dichlorobenzen-1-ide (1/1/1)

Base Information

• Chemical Name: Magnesium bromide 3,5-dichlorobenzen-1-ide (1/1/1)
• CAS No.: 82297-90-3
• Molecular Formula: C6H3BrCl2Mg
• Molecular Weight: 250.205
• Hs Code.: 29310099
• DSSTox Substance ID: DTXSID60545144
• Mol file: 82297-90-3.mol

Synonyms:Magnesium bromide 3,5-dichlorobenzen-1-ide (1/1/1);magnesium;1,3-dichlorobenzene-5-ide;bromide;DTXSID60545144

Chemical Property of Magnesium bromide 3,5-dichlorobenzen-1-ide (1/1/1)

Chemical Property:

• Boiling Point: 65 °C at 760 mmHg
• Flash Point: 1 °C
• PSA: 0.00000
• Density: 0.972 g/cm³
• LogP: 3.63920
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 247.86456
• Heavy Atom Count: 10
• Complexity: 156

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dichlorophenylmagnesium bromide solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,F+,C
• Hazard Codes: F,C,F+
• Statements: 11-14-19-22-34-40-12-37
• Safety Statements: 16-23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=[C-]C=C(C=C1Cl)Cl.[Mg+2].[Br-]
• Uses: 3,5-Dichlorophenylmagnesium bromide can be used:In one of the key synthetic steps for the preparation of non-alternant polycyclic hydrocarbon named indeno-benzophenalene.As a substrate in the synthesis of carboxylic esters by reacting with 2-methyl-4,6-pyrimidyl dicarbonates.As a substrate in the synthesis of aryl ketones by reacting with acid chlorides using bis[2-(N,N-dimethylamino)ethyl] ether ligand.

Technology Process of Magnesium bromide 3,5-dichlorobenzen-1-ide (1/1/1)

There total 1 articles about Magnesium bromide 3,5-dichlorobenzen-1-ide (1/1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3,5-dichlorobenzene (19752-55-7) → 3,5-dichlorophenylmagnesium bromide (82297-90-3)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield: 87.0%

(2E/Z)-1-(4-bromo-3-methylphenyl)-4,4,4-trifluoro-3-(methoxymethylamino)-2-buten-1-one (1125812-32-9) + (2E/Z)-3-[bis(1-methylethyl)amino]-1-(4-bromo-3-methylphenyl)-4,4,4-trifluoro-2-buten-1-one (1125812-65-8) + 3,5-dichlorophenylmagnesium bromide (82297-90-3) → 1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one (943437-03-4)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 2h;

Reference yield: 85.0%

3,5-dichlorophenylmagnesium bromide (82297-90-3) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → (5-chloro-2-methoxy-phenyl)-(3,5-dichloro-phenyl)-methanone (872088-11-4)

Guidance literature:

With Bis<2-(N,N-dimethylamino)aethyl>aether; In tetrahydrofuran; cooling;

DOI:10.1021/ol052150q

upstream raw materials:

1-bromo-3,5-dichlorobenzene

Downstream raw materials:

2,3-dihydro-9b-(3,5-dichlorophenyl)oxazolo<2,3-a>isoindol-5(9bH)-one

9-(3,5-dichlorophenyl)fluoren-9-ol

(S)-α,α-Bis(3,5-dichlorophenyl)-2-pyrrolidinemethanol

bis(3,5-dichlorophenyl)phosphine oxide

Refernces

• 1、 -. "Process for producing 3,5-dichloro-α-methylstyrene". . . Retrieved 2008/06/13.