(S)-3-aminotetrahydrofuran hydrochloride

Base Information

• Chemical Name: (S)-3-aminotetrahydrofuran hydrochloride
• CAS No.: 204512-95-8
• Molecular Formula: C4H10ClNO
• Molecular Weight: 123.582
• Hs Code.: 2932190090
• European Community (EC) Number: 663-078-0
• DSSTox Substance ID: DTXSID30595393
• Mol file: 204512-95-8.mol

Synonyms:204512-95-8;(S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE;(S)-3-aminotetrahydrofuran hydrochloride;(3S)-oxolan-3-amine hydrochloride;(3s)-oxolan-3-amine;hydrochloride;(S)-Tetrahydro-furan-3-ylamine hydrochloride;3-Furanamine, tetrahydro-, hydrochloride (1:1), (3S)-;(S)-TETRAHYDROFURAN-3-AMINE HCL;(S)-3-Aminotetrahydrofuran, HCl;MFCD08445642;(S)-3-aminotetrahydrofuran HCl;3-Furanamine, tetrahydro-, hydrochloride, (3S)-;(S)-Tetrahydrofuran-3-Aminehydrochloride;(S)-tetrahydrofuran-3-ylamine hydrochloride;SCHEMBL286061;DTXSID30595393;(3S)-3-oxolanamine hydrochloride;(S)-tetrahydrofuran-3-amine-HCl;MHOVLDXJDIEEMJ-WCCKRBBISA-N;BCP06180;AKOS015849614;AKOS015899531;AM62692;CS-W019697;DS-12044;(3S)-Tetrahydro-3-furanamine hydrochloride;(s)-3-aminotetrahydrofuran hydrochloride salt;EN300-256935;(3S)-Oxolan-3-amine--hydrogen chloride (1/1);A814574;(3S)-Tetrahydro-3-furanamine hydrochloride (1:1);(S)-3-Aminotetrahydrofuran hydrochloride, >=97.0% (GC);(S)-Tetrahydro-furan-3-ylamine hydrochloride, AldrichCPR

Chemical Property of (S)-3-aminotetrahydrofuran hydrochloride

Chemical Property:

• Vapor Pressure: 1.09mmHg at 25°C
• Boiling Point: 173.5 °C at 760 mmHg
• Flash Point: 58.7 °C
• PSA: 35.25000
• LogP: 1.23630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 123.0450916
• Heavy Atom Count: 7
• Complexity: 46.8

Purity/Quality:

98% ^*data from raw suppliers

(S)-3-AminotetrahydrofuranHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCC1N.Cl
• Isomeric SMILES: C1COC[C@H]1N.Cl
• Uses: (S)-3-Aminotetrahydrofuran Hydrochloride is an intermediate used to prepare 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors.

Technology Process of (S)-3-aminotetrahydrofuran hydrochloride

There total 4 articles about (S)-3-aminotetrahydrofuran hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-3-benzoylamino-tetrahydrofuran (152495-79-9,872303-09-8) → (3S)-tetrahydrofuran-3-amine hydrochloride (204512-95-8,1185756-83-5,204512-94-7)

Guidance literature:

(S)-3-benzoylamino-tetrahydrofuran; With water; sodium hydroxide; In ethanol; for 10h; Reflux;

With hydrogenchloride; In ethanol; water;

DOI:10.1016/j.tetasy.2013.04.007

Reference yield:

C11H15NO3S (1070789-73-9) → (3S)-tetrahydrofuran-3-amine hydrochloride (204512-95-8,1185756-83-5,204512-94-7)

Guidance literature:

C₁₁H₁₅NO₃S; With methanol; magnesium;

With hydrogenchloride; Product distribution / selectivity;

Reference yield:

C14H15NO3S → (3S)-tetrahydrofuran-3-amine hydrochloride (204512-95-8,1185756-83-5,204512-94-7)

Guidance literature:

C₁₄H₁₅NO₃S; With methanol; magnesium;

With hydrogenchloride; Product distribution / selectivity;

upstream raw materials:

(S)-3-benzoylamino-tetrahydrofuran

C₁₁H₁₅NO₃S

Downstream raw materials:

SNX₀₇₂₃

(S)-2-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzonitrile

(S)-4-bromo-2-(tetrahydrofuran-3-ylamino)benzonitrile

C₂₂H₂₆N₄O₂

Refernces

• 1、 -. "Processes for the Manufacture of Chiral and Racemic Forms of 3-Aminotetrahydrofurans, Their Salts and Derivatives". Page/Page column 3. . Retrieved 2008/12/04.