2-Benzylpiperazine

Base Information

• Chemical Name: 2-Benzylpiperazine
• CAS No.: 84477-71-4
• Molecular Formula: C11H16N2
• Molecular Weight: 176.261
• Mol file: 84477-71-4.mol

Synonyms:Piperazine,2-benzyl- (6CI);2-Benzylpiperazine;3-Benzylpiperazine;

Chemical Property of 2-Benzylpiperazine

Chemical Property:

• Vapor Pressure: 0.00178mmHg at 25°C
• Refractive Index: 1.526
• Boiling Point: 293 °C at 760 mmHg
• Flash Point: 165.8 °C
• PSA: 24.06000
• Density: 0.996 g/cm³
• LogP: 1.44810
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

2-benzylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,C
• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Description: 2-BZP (Item No. 24419) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.

Technology Process of 2-Benzylpiperazine

There total 3 articles about 2-Benzylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-benzyl-piperazine-1-carboxylic acid tert-butyl ester (502649-29-8) → 2-(S)-Benzyl-piperazine (84477-71-4)

Guidance literature:

In acetonitrile; at 300 ℃; under 75007.5 Torr;

DOI:10.1021/acs.orglett.6b00378

Reference yield:

→ 2-(S)-Benzyl-piperazine (84477-71-4) + sodium ethanolate (141-52-6)

Guidance literature:

Reference yield:

N-glycyl-phenylalanine ethyl ester (52555-30-3) → 2-(S)-Benzyl-piperazine (84477-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: elektrochemische Reduktion

With ethanol;

upstream raw materials:

N-glycyl-phenylalanine ethyl ester

3-benzyl-piperazine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "Benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them". . . Retrieved 2008/06/13.