2,6-BIS(TRIFLUOROMETHYL)PYRIDINE

Base Information

• Chemical Name: 2,6-BIS(TRIFLUOROMETHYL)PYRIDINE
• CAS No.: 455-00-5
• Molecular Formula: C7H3F6N
• Molecular Weight: 215.098
• Hs Code.: 29333990
• Mol file: 455-00-5.mol

Synonyms:2,6-bis(trifluoromethyl)pyridine

Chemical Property of 2,6-BIS(TRIFLUOROMETHYL)PYRIDINE

Chemical Property:

• Vapor Pressure: 37.3mmHg at 25°C
• Melting Point: 55-59 °C
• Refractive Index: 1.375
• Boiling Point: 103.5 °C at 760 mmHg
• PKA: -4.12±0.24(Predicted)
• Flash Point: 16.4 °C
• PSA: 12.89000
• Density: 1.437 g/cm³
• LogP: 3.11920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Bis(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, F, Xi
• Hazard Codes: F,T,Xi
• Statements: 11-25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-BIS(TRIFLUOROMETHYL)PYRIDINE

There total 2 articles about 2,6-BIS(TRIFLUOROMETHYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

copper(l) iodide (7681-65-4) + tetraphenylphosphonium bis(trifluoromethyl)copper(I) + 2-bromo-6-(trifluoromethyl)pyridine (189278-27-1) → 2,6-bis-(trifluoromethyl)pyridine (455-00-5) + tetraphenylphosphonium (trifluoromethyl)copper(I)iodide

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.1c07408

Reference yield:

pyridine (110-86-1) + iodotrifluoromethane (2314-97-8,263005-66-9) → 4-trifluoromethylpyridine (3796-24-5) + 3-(trifluoromethyl)pyridine (3796-23-4) + 3,5-bis(trifluoromethyl)pyridine (20857-47-0) + 2,6-bis-(trifluoromethyl)pyridine (455-00-5) + 2-(trifluoromethyl)pyridine (368-48-9)

Guidance literature:

for 96h; Product distribution; Irradiation; The yields, the kind of products depend on the time of the irrad. and/or the temp., and the mol. ratio. Other trifluorometh. agents investigated;

DOI:10.1016/S0022-1139(00)80523-0

Reference yield: 52.0%

2,6-bis-(trifluoromethyl)pyridine (455-00-5) → (2,6-bis(trifluoromethyl)pyridin-4-yl)boronic acid (1653975-45-1)

Guidance literature:

With Triisopropyl borate; lithium diisopropyl amide; In diethyl ether; at -78 ℃;

DOI:10.1016/j.dyepig.2021.109733

upstream raw materials:

pyridine

iodotrifluoromethane

copper(l) iodide

2-bromo-6-(trifluoromethyl)pyridine

Downstream raw materials:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-bis(trifluoromethyl)pyridine

(2,6-bis(trifluoromethyl)pyridin-4-yl)boronic acid

4-(p-tolyl)-2,6-bis(trifluoromethyl)pyridine

Refernces