3,3-Dimethylpiperidine hydrochloride

Base Information

• Chemical Name: 3,3-Dimethylpiperidine hydrochloride
• CAS No.: 27832-58-2
• Molecular Formula: C7H15 N . Cl H
• Molecular Weight: 149.66
• Hs Code.: 2933399090
• European Community (EC) Number: 689-995-6
• DSSTox Substance ID: DTXSID00595582
• Mol file: 27832-58-2.mol

Synonyms:3,3-Dimethylpiperidine hydrochloride;27832-58-2;3,3-dimethylpiperidine;hydrochloride;3,3-DIMETHYLPIPERIDINE HCL;MFCD00465824;Piperidine, 3,3-dimethyl-, hydrochloride (1:1);Piperidine, 3,3-dimethyl-, hydrochloride;SCHEMBL82638;DTXSID00595582;BXFKQBZPFQBCCO-UHFFFAOYSA-N;CHEBI:194718;3,3-Dimethylpiperidinehydrochloride;AKOS005255262;SB12972;MS-20067;DB-067834;CS-0054414;Piperidine,3,3-dimethyl-,hydrochloride(1:1);EN300-171206;3,3-Dimethylpiperidine--hydrogen chloride (1/1);A918659;J-511089

Chemical Property of 3,3-Dimethylpiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.735mmHg at 25°C
• Melting Point: 140-143°C
• Boiling Point: 181.3°Cat760mmHg
• Flash Point: 63.5°C
• PSA: 12.03000
• Density: g/cm³
• LogP: 2.52680
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 149.0971272
• Heavy Atom Count: 9
• Complexity: 76.5

Purity/Quality:

98%min ^*data from raw suppliers

3,3-DimethylpiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCNC1)C.Cl

Technology Process of 3,3-Dimethylpiperidine hydrochloride

There total 1 articles about 3,3-Dimethylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethylglutarimide (1194-33-8) → 3,3-dimethylpiperidine hydrochloride (27832-58-2)

Guidance literature:

2,2-dimethylglutarimide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 10h; Heating / reflux;

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

With hydrogenchloride; In diethyl ether; at 0 ℃; for 1h;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,2,2-trifluoro-N-{4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}acetamide + 3,3-dimethylpiperidine hydrochloride (27832-58-2) → 5-[(3,3-dimethylpiperidin-1-yl)methyl]-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

Guidance literature:

formaldehyd; 2,2,2-trifluoro-N-{4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}acetamide; 3,3-dimethylpiperidine hydrochloride; With acetic acid; N-ethyl-N,N-diisopropylamine; In water; at 60 ℃; for 2h;

With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 80 ℃;

DOI:10.1016/j.bmc.2020.115531

upstream raw materials:

2,2-dimethylglutarimide

Refernces