tert-Butyl 4-aminopiperidine-1-carboxylate hydrochloride

Base Information

• Chemical Name: tert-Butyl 4-aminopiperidine-1-carboxylate hydrochloride
• CAS No.: 189819-75-8
• Molecular Formula: C₁₀H₂₀N₂O₂*ClH
• Molecular Weight: 236.742
• Hs Code.: 29333990
• DSSTox Substance ID: DTXSID70373197
• Mol file: 189819-75-8.mol

Synonyms:189819-75-8;tert-Butyl 4-aminopiperidine-1-carboxylate hydrochloride;4-Amino-1-Boc-piperidine hydrochloride;1-Boc-4-aminopiperidine hydrochloride;1-BOC-4-AMINO-PIPERIDINE HYDROCHLORIDE;1-Boc-4-amino-piperidine, HCl;tert-butyl 4-aminopiperidine-1-carboxylate;hydrochloride;1-Piperidinecarboxylic acid, 4-amino-, 1,1-dimethylethyl ester, hydrochloride (1:1);MFCD01321014;4-amino-1-boc-piperidine hcl;1-BOC-4-AMINO-PIPERIDINE HCL;1-Boc-4-Aminopiperidine HCl;SCHEMBL307023;tert-butyl 4-aminopiperidine-1-carboxylate,hydrochloride;DTXSID70373197;KLOQZAJAQQKCNC-UHFFFAOYSA-N;4-amino-Boc-piperidine hydrochloride;AKOS015847933;4-amino-N-Boc-piperidine hydrochloride;AC-4612;boc-(4-amino)-piperidine hydrochloride;CS-W014154;SB43307;AS-73947;1-BOC-4-AMINO-PIPERIDINEHYDROCHLORIDE;AM20090108;FT-0657752;4-amino-1-t-butoxycarbonylpiperidine hydrochloride;1-Butyloxycarbonyl-4-amino-piperidine hydrochloride;J-504371;4-amino-1-tert-butoxycarbonyl piperidine hydrochloride;tert-Butyl4-aminopiperidine-1-carboxylatehydrochloride;4-Amino-1-Boc-piperidine hydrochloride, >=97.0% (N);tert-butyl 4-amino-piperidine-1-carboxylate hydrochloride;tert-Butyl-4-amino-1-piperidinecarboxylate hydrochloride;4-amino-piperidine-1-carboxylic acid tert-butyl ester hydrochloride;tert-Butyl 4-aminopiperidine-1-carboxylate--hydrogen chloride (1/1);1-Piperidinecarboxylicacid,4-amino-,1,1-dimethylethyl ester,hydrochloride(1:1)

Chemical Property of tert-Butyl 4-aminopiperidine-1-carboxylate hydrochloride

Chemical Property:

• Boiling Point: 277.3 °C at 760 mmHg
• Flash Point: 121.5 °C
• PSA: 55.56000
• LogP: 2.78480
• Storage Temp.: Store at -15°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 236.1291556
• Heavy Atom Count: 15
• Complexity: 203

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl4-Aminopiperidine-1-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)N.Cl

Technology Process of tert-Butyl 4-aminopiperidine-1-carboxylate hydrochloride

There total 1 articles about tert-Butyl 4-aminopiperidine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-amino-1-(t-butoxycarbonyl)piperidine monohydrochloride (189819-75-8)

Guidance literature:

Reference yield: 67.0%

4-amino-1-(t-butoxycarbonyl)piperidine monohydrochloride (189819-75-8) + (1-oxo-1,3-dihydro-2H-isoindol-2-yl)carboxylic acid (39221-42-6) → tert butyl 4-(2-(1-oxoisoindolin-2-yl)acetamido)piperidine-1-carboxylate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b00777

Reference yield:

4-amino-1-(t-butoxycarbonyl)piperidine monohydrochloride (189819-75-8) → lithium 4-((1-(methoxycarbonyl)piperidin-4-yl)(methyl)carbamoyl)benzoate

Guidance literature:

Multi-step reaction with 5 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4: triethylamine; dmap / dichloromethane / 17 h / 20 °C

5: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 3 h / 20 °C

With hydrogenchloride; dmap; lithium hydroxide monohydrate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Refernces