3-BROMO-1H-PYRAZOLO[3,4-C]PYRIDINE

Base Information

• Chemical Name: 3-BROMO-1H-PYRAZOLO[3,4-C]PYRIDINE
• CAS No.: 76006-13-8
• Molecular Formula: C₆H₄BrN₃
• Molecular Weight: 198.022
• Hs Code.: 2933990090
• Mol file: 76006-13-8.mol

Synonyms:3-Bromo-1H-pyrazolo[3,4-c]pyridine;

Chemical Property of 3-BROMO-1H-PYRAZOLO[3,4-C]PYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 208-210 °C
• Refractive Index: 1.746
• Boiling Point: 378.612 °C at 760 mmHg
• PKA: 8.76±0.40(Predicted)
• Flash Point: 182.778 °C
• PSA: 41.57000
• Density: 1.895 g/cm³
• LogP: 1.72040
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-1H-pyrazolo[3,4-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-1H-pyrazolo[3,4-c]pyridine is a useful reactant for the synthesis of azaindazoles as Inhibitors of bacterial DNA Ligase.

Technology Process of 3-BROMO-1H-PYRAZOLO[3,4-C]PYRIDINE

There total 5 articles about 3-BROMO-1H-PYRAZOLO[3,4-C]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-diazo-3H-pyrazolo<3,4-c>pyridine (76006-18-3) → 3-bromo-1H-pyrazolo[3,4-c]pyridine (76006-13-8)

Guidance literature:

With hydrogen bromide; for 0.333333h; Heating;

Reference yield: 69.0%

1H-pyrazolo[3,4-c]pyridine (271-47-6) → 3-bromo-1H-pyrazolo[3,4-c]pyridine (76006-13-8)

Guidance literature:

With sodium hypobromide; In water; at 0 ℃; for 1h;

DOI:10.1002/ardp.19893221209

Reference yield:

3-Nitro-1H-pyrazolo<3,4-c>pyridine (76006-15-0) → 3-bromo-1H-pyrazolo[3,4-c]pyridine (76006-13-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / hydrogen / palladium-charcoal (10percent) / ethanol / 1520 Torr

2: 97 percent / sodium nitrite, aq. sulphuric acid / 0.5 h

3: 94 percent / 60percent hydrobromic acid / 0.33 h / Heating

With sulfuric acid; hydrogen bromide; hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol;

upstream raw materials:

3-diazo-3H-pyrazolo<3,4-c>pyridine

1H-pyrazolo[3,4-c]pyridine

1H-pyrazolo[3,4-c]pyridin-3-amine

3-Nitro-1H-pyrazolo<3,4-c>pyridine

Refernces

• 1、 -. "Heterocyclic substituted 2-methyl-benzimidazole antiviral agents". . . Retrieved 2008/06/13.
• 2、 Chapman, David,Hurst, Jim. "Pyrazolopyridines. Part 5. Preparation and Reactions of Pyrazolopyridines". . p. 2398 - 2404. Retrieved 2007/10/02.