3,5-DIMETHYLISATOIC ANHYDRIDE

Base Information

• Chemical Name: 3,5-DIMETHYLISATOIC ANHYDRIDE
• CAS No.: 56934-87-3
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.18
• Hs Code.: 2934999090
• Mol file: 56934-87-3.mol

Synonyms:3,5-Dimethylisatoicanhydride;

Chemical Property of 3,5-DIMETHYLISATOIC ANHYDRIDE

Chemical Property:

• Refractive Index: 1.568
• PSA: 63.07000
• Density: 1.284g/cm³
• LogP: 1.09810
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dimethylisatoicanhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHYLISATOIC ANHYDRIDE

There total 3 articles about 3,5-DIMETHYLISATOIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

carbon dioxide (124-38-9,18923-20-1) + carbon monoxide (201230-82-2) + 2-iodo-4,6-dimethylaniline (4102-54-9) → 6,8-dimethyl-1H-benzo[d][1,3]oxazine-2,4-dione (56934-87-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium acetate; In tetrahydrofuran; at 60 ℃; for 16h;

DOI:10.1021/acscatal.7b03000

Reference yield: 36.0%

carbon monoxide (201230-82-2) + 2-iodo-4,6-dimethylaniline (4102-54-9) → 6,8-dimethyl-1H-benzo[d][1,3]oxazine-2,4-dione (56934-87-3)

Guidance literature:

With potassium phosphate; oxygen; palladium diacetate; potassium iodide; calcium chloride; copper dichloride; Trimethylacetic acid; In acetonitrile; at 100 ℃; for 36h; under 2280.15 Torr;

DOI:10.1021/jo500417u

Reference yield:

→ 6,8-dimethyl-1H-benzo[d][1,3]oxazine-2,4-dione (56934-87-3)

Guidance literature:

2-Amino-3,5-dimethylbenzoesaeure, fl. Phosgen, Dioxan, 45gradC;

DOI:10.1021/jm00243a014

upstream raw materials:

carbon monoxide

2-iodo-4,6-dimethylaniline

carbon dioxide

Downstream raw materials:

2-amino-3,5-dimethylbenzohydrazide

2-Amino-3,5-dimethylbenzamide

Refernces

• 1、 Gao, Sha,Chen, Ming,Zhao, Mi-Na,Du, Wei,Ren, Zhi-Hui,Wang, Yao-Yu,Guan, Zheng-Hui. "Palladium-catalyzed carbonylation of o-iodoanilines for synthesis of isatoic anhydrides". . p. 4196 - 4200. Retrieved 2014/05/20.
• 2、 Sellstedt,Guinosso,Begany,Bell,Rosenthale. "Oxanilic acids, a new series of orally active antiallergic agents". . p. 926 - 933. Retrieved 2007/10/05.