C₁₉H₁₇NO₂S

Base Information

• Chemical Name: C₁₉H₁₇NO₂S
• CAS No.: 1432510-79-6
• Molecular Formula: C₁₉H₁₇NO₂S
• Molecular Weight: 323.415
• Mol file: 1432510-79-6.mol

Synonyms:C₁₉H₁₇NO₂S

Chemical Property of C₁₉H₁₇NO₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇NO₂S

There total 5 articles about C₁₉H₁₇NO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

benzyl 2-{[(tert-butoxy)carbonyl]amino}-4-(4-methylphenyl)thiophene-3-carboxylate (1432511-20-0) → C19H17NO2S (1432510-79-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2013.03.019

Reference yield:

para-methylacetophenone (122-00-9) → C19H17NO2S (1432510-79-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ammonium acetate; acetic acid / toluene / Dean-Stark; Reflux

1.2: 3 h / 50 °C

2.1: dmap / pyridine / 3.17 h / 0 - 55 °C

3.1: potassium hydroxide; water / ethanol / 5 h / Reflux

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 18 h / 20 °C

4.2: 55 °C

5.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With dmap; ammonium acetate; water; acetic acid; 1,1'-carbonyldiimidazole; trifluoroacetic acid; potassium hydroxide; In pyridine; ethanol; dichloromethane; toluene; 1.1: |Gewald Aminoheterocycles Synthesis / 1.2: |Gewald Aminoheterocycles Synthesis;

DOI:10.1016/j.bmcl.2013.03.019

Reference yield:

ethyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate (15854-08-7) → C19H17NO2S (1432510-79-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dmap / pyridine / 3.17 h / 0 - 55 °C

2.1: potassium hydroxide; water / ethanol / 5 h / Reflux

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 18 h / 20 °C

3.2: 55 °C

4.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With dmap; water; 1,1'-carbonyldiimidazole; trifluoroacetic acid; potassium hydroxide; In pyridine; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2013.03.019

upstream raw materials:

para-methylacetophenone

2-{[( tert-butoxy)carbonyl]amino}-4-(4-methylphenyl)thiophene-3-carboxylic acid

benzyl alcohol

ethyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate

Refernces