2-Piperidinol

Base Information

• Chemical Name: 2-Piperidinol
• CAS No.: 45506-41-0
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• European Community (EC) Number: 610-256-0
• DSSTox Substance ID: DTXSID90423183
• Nikkaji Number: J652.434F
• Mol file: 45506-41-0.mol

Synonyms:2-Piperidinol;piperidin-2-ol;45506-41-0;2-HYDROXYPIPERIDINE;SCHEMBL69143;DTXSID90423183;AKOS005206926;MB03551;FT-0639849;A826828

Chemical Property of 2-Piperidinol

Chemical Property:

• Boiling Point: 180.447 °C at 760 mmHg
• Flash Point: 93.703 °C
• PSA: 32.26000
• Density: 1.017 g/cm³
• LogP: 0.40710
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 101.084063974
• Heavy Atom Count: 7
• Complexity: 56

Purity/Quality:

99% ^*data from raw suppliers

Piperidin-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)O

Technology Process of 2-Piperidinol

There total 3 articles about 2-Piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidin-2-one (675-20-7) → 2-hydroxy-piperidine (45506-41-0)

Guidance literature:

With sodium tetrahydroborate; cobalt(II) acetate; In water; at 15 - 25 ℃; for 12h;

Reference yield:

Cyclopentanone oxime (1192-28-5) → 2-hydroxy-piperidine (45506-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 6 h / 30 - 35 °C

2: cobalt(II) acetate; sodium tetrahydroborate / water / 12 h / 15 - 25 °C

With sodium tetrahydroborate; thionyl chloride; cobalt(II) acetate; In dichloromethane; water;

Reference yield:

cyclopentanone (120-92-3) → 2-hydroxy-piperidine (45506-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; hydroxylamine hydrochloride / water / 3.5 h / 20 - 30 °C

2: thionyl chloride / dichloromethane / 6 h / 30 - 35 °C

3: cobalt(II) acetate; sodium tetrahydroborate / water / 12 h / 15 - 25 °C

With sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; cobalt(II) acetate; sodium hydroxide; In dichloromethane; water;

upstream raw materials:

Cyclopentanone oxime

piperidin-2-one

cyclopentanone

Downstream raw materials:

2,3-dichloro-pyridine

(2-oxopiperidine-1-yl)chlorobenzene

Refernces