2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate

Base Information

• Chemical Name: 2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate
• CAS No.: 101385-69-7
• Molecular Formula: C5H10ClF6N2P
• Molecular Weight: 278.56
• Hs Code.: 29332900
• Mol file: 101385-69-7.mol

Synonyms:2-CHLORO-1,3-DIMETHYLIMIDAZOLINIUM HEXAFLUOROPHOSPHATE;CIP Reagent;

Chemical Property of 2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate

Chemical Property:

• Melting Point: 231-233 °C(lit.)
• PSA: 19.84000
• LogP: 3.44800
• Storage Temp.: 2-8°C
• Sensitive.: Moisture & Light Sensitive
• Solubility.: acetonitrile: 0.1 g/mL, clear

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-1,3-dimethyl-4,5-dihydro-1H-imidazol-3-iumHexafluorophosphate(V) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for synthesis of: Diazo-transfer reagents Reagent for synthesis of: Cannabinoid CB1 receptor agonists Selective small-molecule melanocortin-4 receptor agonists Imidazoles as selective cannabinoid CB2 receptor antagonists Cyclic alpha-peptoids Cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor

Technology Process of 2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate

There total 3 articles about 2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-1,3-dimethylimidazolinium chloride (37091-73-9) → 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate (101385-69-7)

Guidance literature:

With sodium hexaflorophosphate; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201406694

Reference yield:

1,3-dimethyl-2-imidazolidinone (80-73-9) → 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate (101385-69-7)

Guidance literature:

With potassium hexafluorophosphate;

DOI:10.1021/ol006322p

Reference yield:

1,1'-carbonyldipyrrolidine (81759-25-3) → 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate (101385-69-7)

Guidance literature:

With potassium hexafluorophosphate; oxalyl dichloride; water; Yield given. Multistep reaction; 1.) CH₂Cl₂, reflux, 3 h, 2.) CH₂Cl₂, 0 deg C, 5 min;

DOI:10.1080/00304949809355316

upstream raw materials:

1,1'-carbonyldipyrrolidine

1,3-dimethyl-2-imidazolidinone

2-chloro-1,3-dimethylimidazolinium chloride

Downstream raw materials:

2-azido-1,3-dimethyl-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate (V)

2-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-1,3-dimethyl-4,5-dihydro-1H-imidazol-3-ium hexafluorophosphate

Refernces

• 1、 Depaix, Ana?s,Peyrottes, Suzanne,Roy, Béatrice. "One-Pot Synthesis of Nucleotides and Conjugates in Aqueous Medium". . p. 241 - 245. Retrieved 2017.
• 2、 Fairbanks, Antony J.. "Applications of Shoda's reagent (DMC) and analogues for activation of the anomeric centre of unprotected carbohydrates". . . Retrieved 2020/12/07.
• 3、 Lim, David,Brimble, Margaret A.,Kowalczyk, Renata,Watson, Andrew J.A.,Fairbanks, Antony John. "Protecting-group-free one-pot synthesis of glycoconjugates directly from reducing sugars". . p. 11907 - 11911. Retrieved 2015/02/19.