GLYCINE-2,2-D2

Base Information

• Chemical Name: GLYCINE-2,2-D2
• CAS No.: 4896-75-7
• Molecular Formula: C2H3D2NO2
• Molecular Weight: 77.0513
• Mol file: 4896-75-7.mol

Synonyms:2,2-Dideuterioglycine;

Chemical Property of GLYCINE-2,2-D2

Chemical Property:

• Melting Point: 240 °C (dec.)(lit.)
• Boiling Point: 240.9 °C at 760 mmHg
• Flash Point: 99.5 °C
• PSA: 63.32000
• Density: 1.287 g/cm³
• LogP: -0.27000
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycine-d2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Glycine-d2, is the labeled analogue of Glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Technology Process of GLYCINE-2,2-D2

There total 4 articles about GLYCINE-2,2-D2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

glycine (56-40-6,18875-39-3,25718-94-9) → <2-2H2>glycine (4896-75-7)

Guidance literature:

With deuteroacetic acid; salicylaldehyde; at 100 ℃; for 1h;

DOI:10.1002/(SICI)1099-1344(200004)43:5<449::AID-JLCR331>3.0.CO;2-0

Reference yield:

Glyoxilic acid (298-12-4) → <2-2H2>glycine (4896-75-7)

Guidance literature:

With water-d2; transaminase;

Reference yield:

(RS)-serine-2-d (53170-89-1) → <2-2H2>glycine (4896-75-7)

Guidance literature:

With water-d2; serine tetrahydrofolate methyl transferase;

upstream raw materials:

glycine

Glyoxilic acid

(RS)-serine-2-d

Downstream raw materials:

methyl <2-²H₂>glycinate hydrochloride

Z-<2-2H2>Gly

C₆H₉⁽²⁾H₂NO₃

C₈H₁₃⁽²⁾H₂NO₃

Refernces

• 1、 -. "SUBSTITUTED BORIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND APPLICATION THEREOF". Paragraph 0038; 0039. . Retrieved 2019/05/10.
• 2、 Michelotti, Alessia,Rodrigues, Fabien,Roche, Maxime. "Development and Scale-Up of Stereoretentive α-Deuteration of Amines". supporting information. p. 1741 - 1744. Retrieved 2017/11/24.