NORDIAZEPAM-D5

Base Information

• Chemical Name: NORDIAZEPAM-D5
• CAS No.: 65891-80-7
• Molecular Formula: C₁₅H₁₁ClN₂O
• Molecular Weight: 275.678
• Mol file: 65891-80-7.mol

Synonyms:2H-1, 4-benzodiazepin-2-one, 7-chloro-1, 3-dihydro-5-(phenyl-d₅)-;

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of NORDIAZEPAM-D5

Chemical Property:

• Melting Point: 214-217°C
• Boiling Point: 453.103 °C at 760 mmHg
• Flash Point: 227.829 °C
• PSA: 41.46000
• Density: 1.348 g/cm³
• LogP: 2.70310
• Storage Temp.: 2-8°C

Purity/Quality:

Safty Information:

• Pictogram(s): Xn, T, F
• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 36-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The primary labelled metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic. Controlled substance (depressant).

Technology Process of NORDIAZEPAM-D5

There total 2 articles about NORDIAZEPAM-D5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-5-chlorobenzonitrile (5922-60-1) → 7-chloro-1,3-dihydro-5-(phenyl-d5)-2H-1,4-benzodiazepine-2-one (65891-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5,5'-dimethyl-2,2'-bipyridine; palladium(II) trifluoroacetate; methanesulfonic acid / 2-methyltetrahydrofuran; water / 12 h / 80 °C / Sealed tube; Inert atmosphere; Cooling with ice

2: pyridine / 20 °C

With pyridine; 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; In 2-methyltetrahydrofuran; water;

Reference yield:

d5-phenylboronic acid → 7-chloro-1,3-dihydro-5-(phenyl-d5)-2H-1,4-benzodiazepine-2-one (65891-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5,5'-dimethyl-2,2'-bipyridine; palladium(II) trifluoroacetate; methanesulfonic acid / 2-methyltetrahydrofuran; water / 12 h / 80 °C / Sealed tube; Inert atmosphere; Cooling with ice

2: pyridine / 20 °C

With pyridine; 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; In 2-methyltetrahydrofuran; water;

upstream raw materials:

2-amino-5-chlorobenzonitrile

Refernces