(4'-Methoxy[1,1'-biphenyl]-4-yl)methanol

Base Information

• Chemical Name: (4'-Methoxy[1,1'-biphenyl]-4-yl)methanol
• CAS No.: 20854-60-8
• Molecular Formula: C14H14O2
• Molecular Weight: 214.26
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID30359992
• Wikidata: Q82141468
• Mol file: 20854-60-8.mol

Synonyms:20854-60-8;(4'-methoxy[1,1'-biphenyl]-4-yl)methanol;[4-(4-methoxyphenyl)phenyl]methanol;4'-Methoxy-[1,1'-biphenyl]-4-methanol;(4'-Methoxy-[1,1'-biphenyl]-4-yl)methanol;(4'-Methoxybiphenyl-4-yl)-methanol;{4'-METHOXY-[1,1'-BIPHENYL]-4-YL}METHANOL;[1,1'-Biphenyl]-4-methanol,4'-methoxy-;Oprea1_606510;SCHEMBL6285826;DTXSID30359992;GVRSPKZCGUMKFK-UHFFFAOYSA-N;4-(4'-methoxyphenyl)benzylalcohol;(4'-methoxybiphenyl-4-yl)methanol;MFCD01862509;(4'-Methoxy-biphenyl-4-yl)-methanol;AKOS002683031;BB 0224052;CS-0196172;A50591;AN-278/13643016

Chemical Property of (4'-Methoxy[1,1'-biphenyl]-4-yl)methanol

Chemical Property:

• Boiling Point: 376 °C at 760 mmHg
• Flash Point: 173.5 °C
• PSA: 29.46000
• Density: 1.112 g/cm³
• LogP: 2.85450
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 189

Purity/Quality:

99% ^*data from raw suppliers

(4'-Methoxy-biphenyl-4-yl)-methanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC=C(C=C2)CO

Technology Process of (4'-Methoxy[1,1'-biphenyl]-4-yl)methanol

There total 16 articles about (4'-Methoxy[1,1'-biphenyl]-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-(4'-methoxyphenyl)benzoate (729-17-9) → (4'-methoxy[1,1'-biphenyl]-4-yl)methanol (20854-60-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield: 93.0%

4-chloromethoxybenzene (623-12-1) + p-hydroxymethylphenylboronic acid (59016-93-2) → (4'-methoxy[1,1'-biphenyl]-4-yl)methanol (20854-60-8)

Guidance literature:

With C₃₇H₄₄ClN₂O₃PPd; caesium carbonate; In water; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1007/s11243-016-0036-5

Reference yield: 93.0%

4-methoxyphenylboronic acid (5720-07-0) + para-Chlorobenzyl alcohol (873-76-7) → (4'-methoxy[1,1'-biphenyl]-4-yl)methanol (20854-60-8)

Guidance literature:

With [PdCl[(η⁵-C₅H₅)]Fe[(η⁵-C₅H₃)-C(CH₃)=NOH](2-dicyclohexylphosphanyl-2'-(N,N-dimethylamino)biphenyl)]; caesium carbonate; In water; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.5012/bkcs.2014.35.8.2551

upstream raw materials:

4′-methoxy-[1,1′-biphenyl]-4-carbonyl chloride

4'-methoxy-biphenyl-4-carboxylic acid

methyl 4-(4'-methoxyphenyl)benzoate

1-(4'-methoxy-biphenyl-4-yl)-ethanone

Downstream raw materials:

4-(4-tolyl)anisole

Refernces

• 1、 Burawoy,Spinner. "-". . p. 2557,2563. Retrieved 1955.
• 2、 Gao, Tingjun,Gao, Yanan,Hu, Hui,Li, Yaling,Su, Xiaofang,Wu, Jifeng,Xu, Huanjun,Zeng, Chaoyuan,Zhang, Xiaosong,Zuo, Kaiming. "Bimetallic docked covalent organic frameworks with high catalytic performance towards coupling/oxidation cascade reactions". . p. 4874 - 4882. Retrieved 2022/02/19.
• 3、 Oloyede, Hammed Olawale,Orighomisan Woods, Joseph Anthony,G?rls, Helmar,Plass, Winfried,Eseola, Abiodun Omokehinde. "N-donor-stabilized Pd(II) species supported by sulphonamide-azo ligands: Ligand architecture, solvent co-ligands, C–C coupling". . . Retrieved 2019/09/10.