2-BIPHENYL-4-YL-1H-INDOLE

Base Information

• Chemical Name: 2-BIPHENYL-4-YL-1H-INDOLE
• CAS No.: 21470-37-1
• Molecular Formula: C20H15N
• Molecular Weight: 269.346
• Hs Code.: 2933990090
• Mol file: 21470-37-1.mol

Synonyms:2-(4-Phenylphenyl)-1H-indole;

Chemical Property of 2-BIPHENYL-4-YL-1H-INDOLE

Chemical Property:

• Vapor Pressure: 3.98E-10mmHg at 25°C
• Melting Point: 302-304 °C
• Refractive Index: 1.678
• Boiling Point: 513 °C at 760 mmHg
• PKA: 16.68±0.30(Predicted)
• Flash Point: 229.9 °C
• PSA: 15.79000
• Density: 1.158 g/cm³
• LogP: 5.50190
• Sensitive.: Light Sensitive

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(4-Biphenylyl)indole >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BIPHENYL-4-YL-1H-INDOLE

There total 21 articles about 2-BIPHENYL-4-YL-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Bromo-4'-phenylacetophenone (135-73-9) + aniline (62-53-3) → 2-((1,1′-biphenyl)-4-yl)-1H-indole (21470-37-1)

Guidance literature:

With N-methylimidazolium trifluoromethanesulfonate ionic liquid supported on nano-silica; In neat (no solvent); at 110 ℃; for 0.5h; Green chemistry;

DOI:10.1007/s13738-015-0603-2

Reference yield: 78.0%

4-((2-bromophenyl)ethynyl)-1,1'-biphenyl (383191-51-3) → 2-((1,1′-biphenyl)-4-yl)-1H-indole (21470-37-1)

Guidance literature:

With (R)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium tert-butylate; ammonia; In 1,4-dioxane; at 90 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c1cc11874a

Reference yield: 67.0%

2-([1,1'-biphenyl]-4-yl)-1-(pyrimidin-2-yl)-1H-indole → 2-((1,1′-biphenyl)-4-yl)-1H-indole (21470-37-1)

Guidance literature:

With sodium ethanolate; In ethanol; dimethyl sulfoxide; at 100 ℃; for 20h;

DOI:10.1021/jacs.7b11591

upstream raw materials:

1-biphenyl-4-yl-ethanone-phenylhydrazone

2-diazo-1-biphenyl-4-yl-ethanone

aniline

biphenyl-4-acetaldehyde

Downstream raw materials:

C₂₉H₂₅NO₃S

2-([1,1'-biphenyl]-4-yl)-4H-benzo[d][1,3]oxazin-4-one

C₃₈H₂₆N₂

2',3'-dimethoxycarbonyl-7'-{2-[2-(4'-biphenylyl)-3-indolyl]ethyl}spiro[fluorene[9,1']-1',8'a-dihydroindolizine]

Refernces

• 1、 Chen, Zhe-Sheng,Dai, Qing-Qing,Li, Guo-Bo,Liu, Hong-Min,Liu, Hui,Wang, Bo,Wang, Shaomeng,Yu, Bin,Yuan, Shuo,Zhang, Jing-Ya,Zhang, Xiao-Nan,Zuo, Jia-Hui. "Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors". . p. 14895 - 14911. Retrieved 2021/10/12.
• 2、 Bzeih, Tourin,Zhang, Kena,Khalaf, Ali,Hachem, Ali,Alami, Mouad,Hamze, Abdallah. "One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles". . p. 228 - 238. Retrieved 2019/01/04.