H-GLY-OIPR HCL

Base Information

• Chemical Name: H-GLY-OIPR HCL
• CAS No.: 14019-62-6
• Molecular Formula: C5H12ClNO2
• Molecular Weight: 153.609
• Hs Code.: 2922499990
• Mol file: 14019-62-6.mol

Synonyms:Glycine,1-methylethyl ester, hydrochloride (9CI);Glycine, isopropyl ester,hydrochloride (7CI,8CI);

Chemical Property of H-GLY-OIPR HCL

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0.979mmHg at 25°C
• Boiling Point: 175.7 °C at 760 mmHg
• Flash Point: 60 °C
• PSA: 52.32000
• Density: 0.987g/cm3
• LogP: 1.39900
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycine isopropyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Glycine isopropyl ester hydrochloride can react with indol-3-yl-oxo-acetyl chloride to produce [2-(1H-indol-3-yl)-2-oxo-acetylamino]-acetic acid isopropyl ester. This reaction will need reagent Et3N, and the menstruum benzene.

Technology Process of H-GLY-OIPR HCL

There total 4 articles about H-GLY-OIPR HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

isopropyl alcohol (67-63-0,8013-70-5) + glycine (56-40-6,18875-39-3,25718-94-9) → glycine isopropyl ester hydrochloride (14019-62-6)

Guidance literature:

With thionyl chloride; for 8h; Schlenk technique; Reflux;

DOI:10.1039/c7ra00073a

Reference yield:

Azido-acetic acid isopropyl ester → glycine isopropyl ester hydrochloride (14019-62-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 45 ℃; for 3h;

DOI:10.1021/jm00119a015

Reference yield:

isopropyl chloroacetate (105-48-6) → glycine isopropyl ester hydrochloride (14019-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaN₃ / dimethylformamide / Ambient temperature

2: 1.) hydrogen, 2.) HCl / Pd-C / ethanol / 3 h / 45 °C

With hydrogenchloride; sodium azide; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00119a015

upstream raw materials:

isopropyl alcohol

glycine

isopropyl chloroacetate

Downstream raw materials:

hydantoic acid isopropyl ester

isopropyl 2-[(E)-1-phenylmethylideneamino]acetate

1-ethyl 3-isopropyl 6-benzyl-2-methyl-5-oxo-5,6-dihydropyrrolo-[1,2-c]quinazoline-1,3-dicarboxylate

C₁₂H₁₅NO₂

Refernces

• 1、 Wei, Qingyi,Wang, Xiaomei,Cheng, Jun-Hu,Zeng, Guangxiang,Sun, Da-Wen. "Synthesis and antimicrobial activities of novel sorbic and benzoic acid amide derivatives". . p. 220 - 232. Retrieved 2018/06/26.
• 2、 Zeng, Debin,Zhang, Rui,Nie, Quandeng,Cao, Lin,Shang, Luqing,Yin, Zheng. "Discovery of 2'-α-C-Methyl-2'-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus". supporting information. p. 1197 - 1201. Retrieved 2016/12/18.