H-ASP-PHE-NH2

Base Information

• Chemical Name: H-ASP-PHE-NH2
• CAS No.: 5241-71-4
• Molecular Formula: C13H17N3O4
• Molecular Weight: 279.296
• Mol file: 5241-71-4.mol

Synonyms:L-α-Aspartyl-L-phenylalaninamide;

Chemical Property of H-ASP-PHE-NH2

Chemical Property:

• Boiling Point: 647 °C at 760 mmHg
• Flash Point: 345.1 °C
• PSA: 135.51000
• Density: 1.326 g/cm³
• LogP: 0.79270
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

H-Asp-Phe-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ASP-PHE-NH2

There total 11 articles about H-ASP-PHE-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-3-tert-Butoxycarbonylamino-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (110575-50-3) → Asp-Phe-NH2 (5241-71-4)

Guidance literature:

With trifluorormethanesulfonic acid; methyl-phenyl-thioether; diphenyl sulfide; In trifluoroacetic acid; at 0 ℃; for 2h;

Reference yield: 97.0%

L-Asp-L-Phe-OMe (22839-47-0,7421-84-3) → Asp-Phe-NH2 (5241-71-4)

Guidance literature:

With ammonia; at -40 ℃; for 10.25h;

Reference yield: 97.0%

→ α-aspartyl phenylalaninamide ammonium salt (251991-33-0) + Asp-Phe-NH2 (5241-71-4)

Guidance literature:

upstream raw materials:

Z-Asp(OBzl)-Phe-NH₂

N-benzyloxycarbonyl-aspartyl-phenylalanine amide

N-α-Fmoc-L-phenylalanine pentafluorophenyl ester

N^α-Fmoc-L-Asn-OPfp

Downstream raw materials:

(S)-3-({2-[1-Amino-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carbonyl}-amino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

L-Methionyl-L-aspartyl-L-phenylalanine amide trifluoroacetate

(S)-3-({2-[1-(2-Amino-acetylamino)-2-(1H-indol-3-yl)-ethyl]-4-butyl-4,5-dihydro-1H-imidazole-4-carbonyl}-amino)-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

<<4(5)R>-2-<1(S)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

Refernces

• 1、 -. "Method for preparing aspartylcyclohexyla laninamide". . . Retrieved 2008/06/13.
• 2、 Schoen, Istvan,Szirtes, Tamas,Rill, Attila,Balogh, Gabor,Vadasz, Zsolt,et al.. "Aspartate Racemization in Synthetic Peptides. Part 2. Tendency to Racemization of Aminosuccinyl Residue". . p. 3213 - 3223. Retrieved 2007/10/02.