(R)-4-NITROMANDELIC ACID

Base Information

• Chemical Name: (R)-4-NITROMANDELIC ACID
• CAS No.: 77977-73-2
• Molecular Formula: C8H7NO5
• Molecular Weight: 197.14488
• Hs Code.: 2918199090
• Mol file: 77977-73-2.mol

Synonyms:Benzeneaceticacid, a-hydroxy-4-nitro-, (R)-;(R)-(-)-p-Nitromandelic acid;(R)-4-Nitromandelic acid;( R)- 4-Nitromandelic Acid;hydroxy(4-nitrophenyl)acetic acid;benzeneacetic acid, α-hydroxy-4-nitro-;p-nitromandelic acid;4-nitrophenylglycolic acid;

Chemical Property of (R)-4-NITROMANDELIC ACID

Chemical Property:

• Vapor Pressure: 2.17E-08mmHg at 25°C
• Refractive Index: 1.634
• Boiling Point: 436.4 °C at 760 mmHg
• Flash Point: 197.5 °C
• PSA: 103.35000
• Density: 1.552 g/cm³
• LogP: 1.23600

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-NITROMANDELIC ACID

There total 3 articles about (R)-4-NITROMANDELIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium oxalate (62-76-0) + 4-nitrobenzaldehdye (555-16-8) → (S)-4-nitromandelic acid (77977-72-1) + (R)-4-nitromandelic acid (77977-73-2)

Guidance literature:

With oxalyl Coenzyme A decarboxylase from Methylorubrum extorquens Y₄₉₇A mutant; oxalyl Coenzyme A synthetase from from Methylorubrum extorquens; thioesterase YciA from Escherichia coli; thiamine diphosphate; ATP; coenzyme A; magnesium chloride; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=6.8; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/anie.201915155

Reference yield:

2-hydroxy-2-(4-nitrophenyl)acetic acid (10098-39-2) → (R)-4-nitromandelic acid (77977-73-2)

Guidance literature:

DOI:10.1021/jm00247a008

Reference yield:

→ (R)-4-nitromandelic acid (77977-73-2)

Guidance literature:

upstream raw materials:

2-hydroxy-2-(4-nitrophenyl)acetic acid

sodium oxalate

4-nitrobenzaldehdye

Refernces

• 1、 Hoover,Dunn,Jakas,Lam,Taggart,Guarini,Phillips. "Semisynthetic cephalosporins. Synthesis and structure activity relationships of 7 mandelamido 3 cephem 4 carboxylic acids". . p. 34 - 41. Retrieved 2007/10/06.