2-METHOXY-D3-PHENOL

Base Information

• Chemical Name: 2-METHOXY-D3-PHENOL
• CAS No.: 74495-69-5
• Molecular Formula: C7H5D3O2
• Molecular Weight: 127.115
• Mol file: 74495-69-5.mol

Synonyms:2-Methoxy-d₃-phenol;

Chemical Property of 2-METHOXY-D3-PHENOL

Chemical Property:

• Boiling Point: 204.999 °C at 760 mmHg
• Flash Point: 83.074 °C
• PSA: 29.46000
• Density: 1.137 g/cm³
• LogP: 1.40080
• Storage Temp.: Refrigerator

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxyphenol-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methoxyphenol-d3 is a compound useful in organic synthesis.

Technology Process of 2-METHOXY-D3-PHENOL

There total 6 articles about 2-METHOXY-D3-PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

1-benzyloxy-2-<2H3>methoxybenzene → o-methoxyphenol-d3 (74495-69-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; for 6h; under 2068.65 Torr;

Reference yield: 82.0%

iodomethane-d3 (865-50-9) + benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → o-methoxyphenol-d3 (74495-69-5)

Guidance literature:

With potassium carbonate; In acetone; at 41 ℃; for 16h;

Reference yield:

O-benzylcatechol (6272-38-4) → o-methoxyphenol-d3 (74495-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Cs₂CO₃ / dimethylformamide / 2 h / Ambient temperature

2: 81 percent / aq. HCl, H₂ / 10percent Pd/C / methanol / 22 h / Ambient temperature

With hydrogenchloride; hydrogen; caesium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

d6-dimethyl sulfate

benzene-1,2-diol

iodomethane-d3

phenol 2-[(tetrahydro-2H-pyran-2yl)oxy]

Downstream raw materials:

2-((2-d3-methoxyphenoxy)-d2-methyl)-d3-oxirane

d3-2-(2-methoxyphenoxy)propanedioic acid diethyl ester

4-hydroxy-3-[²H₃]methoxybenzaldehyde

C₉H₉⁽²⁾H₃O₄

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINES". Page/Page column 35; 37. . Retrieved 2008/12/07.
• 2、 Jacob III, Peyton,Wilson, Margaret,Yu, Lisa,Mendelson, John,Jones, Reese T.. "Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry". . p. 5290 - 5296. Retrieved 2007/10/03.