GAMMA-BUTYROLACTONE-D6

Base Information

• Chemical Name: GAMMA-BUTYROLACTONE-D6
• CAS No.: 77568-65-1
• Molecular Formula: C4D6O2
• Molecular Weight: 92.13
• Mol file: 77568-65-1.mol

Synonyms:GAMMA-BUTYROLACTONE-D6;BUTYROLACTONE-D6;GAMMA-BUTYROLACTONE-D6, 98 ATOM % D;2(3H)-Furanone-3,3,4,5-d4, dihydro-d2-;1,4-Butanolide-d6;1-Oxacyclopentan-2-one-d6;2,3,4,5-Tetrahydro-2-furanone-d6;2-Oxotetrahydrofuran-d6

Chemical Property of GAMMA-BUTYROLACTONE-D6

Chemical Property:

• Vapor Pressure: 0.27mmHg at 25°C
• Melting Point: −45 °C(lit.)
• Refractive Index: n20/D 1.436(lit.)
• Boiling Point: 204 °C at 760 mmHg
• Flash Point: 80.9 °C
• PSA: 26.30000
• Density: 1.208 g/cm³
• LogP: 0.32340
• Storage Temp.: ?20°C

Purity/Quality:

99% ^*data from raw suppliers

γ-Butyrolactone-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,F
• Statements: 22-40-41-36-20/21/22-11-67
• Safety Statements: 26-36-36/37-16-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GAMMA-BUTYROLACTONE-D6

There total 2 articles about GAMMA-BUTYROLACTONE-D6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Acetylenedicarboxylic acid (142-45-0) → <2H6>γ-Butyrolactone (77568-65-1)

Guidance literature:

With deuterium; Ru₄H₄(CO)8(PBu₃)4; In tetrahydrofuran; at 180 ℃; for 48h;

DOI:10.1021/jf070305y

Reference yield: 63.0%

tetrahydrofuran-d8 (1693-74-9) → <2H6>γ-Butyrolactone (77568-65-1)

Guidance literature:

With calcium hypochlorite; In acetic acid; acetonitrile; at 20 ℃; for 22h;

DOI:10.1002/chem.200600799

Reference yield: 69.0%

ethanol (64-17-5) + <2H6>γ-Butyrolactone (77568-65-1) → ethyl 4-chlorohexadeuteriobutanoate (927810-76-2)

Guidance literature:

<2H6>γ-Butyrolactone; With thionyl chloride; for 3h; Heating;

ethanol; for 1.5h; Heating;

DOI:10.1002/chem.200600799

upstream raw materials:

tetrahydrofuran-d8

Acetylenedicarboxylic acid

Downstream raw materials:

ethyl 4-chlorohexadeuteriobutanoate

Refernces

• 1、 Von Seebach, Malte,Kozhushkov, Sergei I.,Schill, Heiko,Frank, Daniel,Boese, Roland,Benet-Buchholz, Jordi,Yufit, Dmitry S.,De Meijere, Armin. "Stereoselective preparation of six diastereomeric quatercyclopropanes from bicyclopropylidene and some derivatives". . p. 167 - 177. Retrieved 2007/10/03.
• 2、 Che, Chi-Ming,Ho, Clare,Lau, Tai-Chu. "Mechanism of C-H Bond Oxidation by a Monooxoruthenium(V) Complex". . p. 1259 - 1263. Retrieved 2007/10/02.