N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

Base Information

• Chemical Name: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
• CAS No.: 406235-30-1
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.293
• Hs Code.: 2933399090
• Mol file: 406235-30-1.mol

Synonyms:4-Hydroxy-4-methylpiperidine-1-carboxylicacid tert-butyl ester;tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate;

Chemical Property of N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.488
• Boiling Point: 296.362 °C at 760 mmHg
• Flash Point: 133.035 °C
• PSA: 49.77000
• Density: 1.076 g/cm³
• LogP: 1.70620
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-butyl4-hydroxy-4-methylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

There total 10 articles about N-BOC-4-METHYL-4-HYDROXY PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methylmagnesium chloride (676-58-4) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (406235-30-1)

Guidance literature:

In tetrahydrofuran; at -78 - 0 ℃; for 2h;

Reference yield: 99.0%

methylmagnesium bromide (75-16-1) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (406235-30-1)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -30 - 23 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja408971t

Reference yield: 94.0%

methyllithium (917-54-4) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate (406235-30-1)

Guidance literature:

In diethyl ether; chloroform; water; at -78 - 20 ℃; for 1.5h;

upstream raw materials:

2,2-dimethylvaleroyl chloride

N-tert-butyloxycarbonylpiperidin-4-one

methylmagnesium chloride

methyllithium

Downstream raw materials:

(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2’-(but-3-en-1-yl)[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-hydroxy-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-(allyloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Refernces

• 1、 -. "DIFLUOROCYCLOHEXYL DERIVATIVES AS IL-17 MODULATORS". Page/Page column 84-85. . Retrieved 2021/09/04.
• 2、 Shibutani, Shotaro,Kodo, Taiga,Takeda, Mitsutaka,Nagao, Kazunori,Tokunaga, Norihito,Sasaki, Yusuke,Ohmiya, Hirohisa. "Organophotoredox-Catalyzed Decarboxylative C(sp3)-O Bond Formation". supporting information. p. 1211 - 1216. Retrieved 2020/02/04.