Lithium tert-butoxide

Base Information

• Chemical Name: Lithium tert-butoxide
• CAS No.: 1907-33-1
• Molecular Formula: C4H9LiO
• Molecular Weight: 80.0559
• Hs Code.: 29051990
• Mol file: 1907-33-1.mol

Synonyms:2-Propanol,2-methyl-, lithium salt (9CI);Lithium tert-butoxide (6CI,7CI);tert-Butylalcohol, lithium salt (8CI);(1,1-Dimethylethoxy)lithium;2-Methyl-2-propanollithium salt;Lithium t-butoxide;Lithium tert-butanolate;Lithiumtert-butylate;tert-Butanol lithium salt;tert-Butoxylithium;

Chemical Property of Lithium tert-butoxide

Chemical Property:

• Appearance/Colour: clear yellow to brown solution
• Melting Point: °C
• Boiling Point: 84.6 °C at 760 mmHg
• Flash Point: 11.7 °C
• PSA: 23.06000
• Density: 0.89 g/mL at 20 °C
• LogP: 1.21540
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• Solubility.: Soluble in toluene, hexane, tetrahydrofuran and methyl tert-buty
• Water Solubility.: vigorous reaction

Purity/Quality:

99.9% ^*data from raw suppliers

Lithium tertiary butoxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, C, N
• Hazard Codes: F,C,N,T
• Statements: 11-19-34-37-35-14-67-65-62-51/53-48/20-40-52/53-36/37/38-25
• Safety Statements: 26-36/37/39-45-61-62-6A-43E-16-7/8-43-33

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Lithium tert-butoxide is a mild base used in organic synthesis. It is involved in the alfa-alkylation reaction of ketones with primary alcohols. It is utilized as a catalyst in the reduction of ketones to the corresponding secondary alcohols. It acts as lithium source utilized in the preparation of LixTiyOz thin films. Further, it is used in conjunction with organometallic reagents/catalysts to modify their reactivity and selectivity.

Technology Process of Lithium tert-butoxide

There total 17 articles about Lithium tert-butoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ lithium tert-butoxide (1907-33-1)

Guidance literature:

Reference yield:

tert-butylperoxytrimethylsilane (3965-63-7) + (2-methylpropyl)lithium (920-36-5,90269-51-5) → 2,5-dimethylhexane (592-13-2) + 1-(1,1-dimethylethoxy)-2-methylpropane (33021-02-2) + lithium trimethylsilanolate (2004-14-0) + lithium tert-butoxide (1907-33-1)

Guidance literature:

In benzene; Further byproducts given;

Reference yield:

tert-butylperoxytrimethylsilane (3965-63-7) + (2-methylpropyl)lithium (920-36-5,90269-51-5) → 2,5-dimethylhexane (592-13-2) + 1-(1,1-dimethylethoxy)-2-methylpropane (33021-02-2) + isobutoxytrimethylsilane (18269-50-6) + lithium trimethylsilanolate (2004-14-0) + isobutene (115-11-7,15220-85-6) + lithium tert-butoxide (1907-33-1)

Guidance literature:

In benzene; Mechanism; other solvent;

upstream raw materials:

n-butyllithium

tert-butylperoxytrimethylsilane

(2-methylpropyl)lithium

tert-butyl alcohol

Downstream raw materials:

(S)-2-phenyl-1-butane

BOC-glycine

1-(tert-butoxycarbonyl)-L-proline

Boc-Trp-OH

Refernces

• 1、 An, Jae Sung,Shin, Won Kyu,An, Duk Keun. "Quantitative synthesis of aldehydes from weinreb amides using lithium diisobutyl-t-butoxyaluminum hydride (LDBBA)". . p. 2928 - 2931. Retrieved 2016/02/05.
• 2、 -. "Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof". Page/Page column 11. . Retrieved 2010/02/15.