Ethyl 1,4-dibenzylpiperazine-2-carboxylate

Base Information

• Chemical Name: Ethyl 1,4-dibenzylpiperazine-2-carboxylate
• CAS No.: 72351-59-8
• Molecular Formula: C21H26N2O2
• Molecular Weight: 338.45
• Hs Code.: 2933599090
• Mol file: 72351-59-8.mol

Synonyms:2-Piperazinecarboxylicacid, 1,4-dibenzyl-, ethyl ester (7CI);1,4-Dibenzylpiperazine-2-carboxylicacid ethyl ester;Ethyl 1,4-bis(phenylmethyl)-2-piperazinecarboxylate;Ethyl1,4-dibenzylpiperazine-2-carboxylate;

Chemical Property of Ethyl 1,4-dibenzylpiperazine-2-carboxylate

Chemical Property:

• Vapor Pressure: 5.2E-08mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 442 °C at 760 mmHg
• PKA: 5.88±0.10(Predicted)
• Flash Point: 221.1 °C
• PSA: 32.78000
• Density: 1.13 g/cm³
• LogP: 2.81190

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl1,4-Dibenzylpiperazine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 1,4-Dibenzylpiperazine-2-carboxylate is one of the reactants in preparation of (benzyl)(alkyl)(imidazolyl)piperazines and isoteric analogs.

Technology Process of Ethyl 1,4-dibenzylpiperazine-2-carboxylate

There total 9 articles about Ethyl 1,4-dibenzylpiperazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-dibromopropionic acid ethyl ester (3674-13-3) + N,N'-Dibenzylethylenediamine (140-28-3,87170-83-0) → ethyl 1,4-dibenzylpiperazin-2-carboxylate (72351-59-8)

Guidance literature:

With triethylamine; In toluene; at 40 - 80 ℃; for 3h;

Reference yield: 100.0%

→ ethyl 1,4-dibenzylpiperazin-2-carboxylate (72351-59-8)

Guidance literature:

Reference yield: 96.0%

N,N-dibenzylethylenediamine (14165-27-6) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → ethyl 1,4-dibenzylpiperazin-2-carboxylate (72351-59-8)

Guidance literature:

With triethylamine; In toluene; at 80 ℃; for 72h;

upstream raw materials:

2,3-dibromopropionic acid ethyl ester

N,N'-Dibenzylethylenediamine

N,N-dibenzylethylenediamine

Ethyl 2-bromopropionate

Downstream raw materials:

ethyl 1-benzylpiperazine-2-carboxylate

1,4-dibenzyl-2-hydroxypiperazine

1,4-dibenzyl-piperazine-2-carboxylic acid propylamide

1,4-dibenzyl-2-piperazinecarboxaldehyde

Refernces

• 1、 -. "2-carboxyl piperazine linked tacrine-8-amino(hydroxyl) quinoline derivative as well as preparation and application". Paragraph 0060-0063. . Retrieved 2019/08/06.
• 2、 El-wahab, Hend A.A. Abd,Accietto, Mauro,Marino, Leonardo B.,McLean, Kirsty J.,Levy, Colin W.,Abdel-Rahman, Hamdy M.,El-Gendy, Mahmoud A.,Munro, Andrew W.,Aboraia, Ahmed S.,Simons, Claire. "Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics". supporting information. p. 161 - 176. Retrieved 2017/11/29.