7-Azabicyclo[2.2.1]heptane hydrochloride

Base Information

• Chemical Name: 7-Azabicyclo[2.2.1]heptane hydrochloride
• CAS No.: 27514-07-4
• Molecular Formula: C6H11N^.HCl
• Molecular Weight: 133.621
• Hs Code.: 2933990090
• European Community (EC) Number: 823-620-0
• DSSTox Substance ID: DTXSID40585846
• Mol file: 27514-07-4.mol

Synonyms:7-azabicyclo[2.2.1]heptane hydrochloride;27514-07-4;7-Azabicyclo[2,2,1]heptane hydrochloride;7-Azabicyclo2,2,1heptane HCl;7-azabicyclo[2.2.1]heptane;hydrochloride;MFCD00154183;7-aza-bicyclo[2.2.1]heptane hydrochloride;7-Azabicyclo[2.2.1]heptane, hydrochloride (1:1);7-Azabicyclo[2.2.1]heptane, HCl;7-AZABICYCLO[2.2.1]HEPTANE HCL;(1S,4S)-7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE;7-azabicyclo[2.2.1]heptanehydrochloride;7-Azabicyclo[2.2.1]heptane, hydrochloride;7-aza-bicyclo [2.2.1]heptane hydrochloride;SCHEMBL225221;SCHEMBL722501;DTXSID40585846;7-Azabicyclo[2,2,1]heptane HCl;AKOS015901135;AKOS025212727;CS-W018698;GS-4015;PB27446;AS-30759;SY020142;A5328;AM20070524;EN300-27295;7-Azabicyclo[2.2.1]heptane hydrochloride (1:1);J-519081;7-Azabicyclo[2.2.1]heptane hydrochloride, AldrichCPR;7-Azabicyclo[2.2.1]heptane--hydrogen chloride (1/1);F8888-7800;Z235340117;7-Azabicyclo[2.2.1]heptane hydrochloride

Chemical Property of 7-Azabicyclo[2.2.1]heptane hydrochloride

Chemical Property:

• Vapor Pressure: 5.17mmHg at 25°C
• Boiling Point: 144.1 °C at 760 mmHg
• Flash Point: 30.6 °C
• PSA: 12.03000
• LogP: 2.03160
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 133.0658271
• Heavy Atom Count: 8
• Complexity: 62.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Azabicyclo[2,2,1]heptaneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2CCC1N2.Cl

Technology Process of 7-Azabicyclo[2.2.1]heptane hydrochloride

There total 20 articles about 7-Azabicyclo[2.2.1]heptane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

trans-4-aminocyclohexyl p-toluensulfonate hydrobromide → 7-azabicyclo[2.2.1]heptane hydrochloride (27514-07-4)

Guidance literature:

trans-4-aminocyclohexyl p-toluensulfonate hydrobromide; With sodium hydroxide; In ethanol; water; at 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In ethanol; water; Inert atmosphere;

Inert atmosphere;

DOI:10.1016/j.bmcl.2012.04.077

Reference yield: 76.0%

C9H14ClNO2 → 7-azabicyclo[2.2.1]heptane hydrochloride (27514-07-4)

Guidance literature:

With hydrogenchloride; In methanol; Reflux;

Reference yield: 72.0%

7-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptane (188624-92-2) → 7-azabicyclo[2.2.1]heptane hydrochloride (27514-07-4)

Guidance literature:

7-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptane; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1016/j.tet.2009.05.007

upstream raw materials:

trans-4-hydroxycyclohexylamine

diethoxyltriphenylphosphorane

7-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptane

trans-4-aminocyclohexanol hydrochloride

Downstream raw materials:

7-phenyloxycarbonyl-7-azabicyclo[2.2.1]heptane

N-(p-chlorobenzoyl)-7-azabicyclo[2.2.1]heptane

N-(p-nitrobenzoyl)-7-azabicyclo[2.2.1]heptane

2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5-(3,5-dimethylphenyl)-4H-thieno[3,2-b]pyrrol-6-yl]ethanol

Refernces

• 1、 -. "CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM". . . Retrieved 2014/09/03.
• 2、 -. "SOLID FORMS OF N-(4-(7-AZABICYCLO[2.2.1]HEPTAN-7-YL)-2-TRIFLUOROMETHYL)PHENYL)-4-OXO-5-(TRIFLUOROMETHYL)-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE". . . Retrieved 2011/05/06.