(R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT

Base Information

• Chemical Name: (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT
• CAS No.: 13613-65-5
• Molecular Formula: C4H7NaO3
• Molecular Weight: 126.088
• Hs Code.: 2918199090
• Mol file: 13613-65-5.mol

Synonyms:Butanoicacid, 3-hydroxy-, monosodium salt, (3R)- (9CI);Butanoic acid, 3-hydroxy-,monosodium salt, (R)-;Butyric acid, 3-hydroxy-, monosodium salt, D-(-)- (8CI);(R)-(-)-Sodium 3-hydroxybutyrate;KTX 0101;Sodium (R)-3-hydroxybutyrate;Sodium D-b-hydroxybutyrate;SodiumR-3-hydroxybutyrate;

Chemical Property of (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT

Chemical Property:

• Vapor Pressure: 0.000979mmHg at 25°C
• Melting Point: 149-155 °C(lit.)
• Boiling Point: 269.2 °C at 760 mmHg
• Flash Point: 121 °C
• PSA: 60.36000
• LogP: -1.49280
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Water (Slightly)

Purity/Quality:

(R)-(?)-3-Hydroxybutyric acid sodium salt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: chiral synthon (R)-(-)-3-Hydroxybutyric acid sodium salt reacts with crown ether to form a supramolecular complex, which can catalyze the regioselective ring-opening polymerization of (S)-butyrolactone to form (R)-3-hydroxybutyrate oligomers (OHBs).

Technology Process of (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT

There total 1 articles about (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.69%

Methyl (R)-3-hydroxybutyrate (3976-69-0) → sodium (R)-3-hydroxybutyrate (13613-65-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 15 ℃; for 12h; Inert atmosphere;

Reference yield: 94.0%

sodium (R)-3-hydroxybutyrate (13613-65-5) → (R)-3-hydroxybutyric acid (625-72-9,26063-00-3,29435-48-1)

Guidance literature:

With DOWEX 50x8-200 ion-exchange resin; In methanol;

DOI:10.1016/0040-4039(95)01318-C

Reference yield: 92.0%

(R)-3-hydroxy-1-(p-toluenesulfonyloxy)butane (75351-36-9) + sodium (R)-3-hydroxybutyrate (13613-65-5) → (R)-3-hydroxybutyrate (R)-1,3-butanediol monoester (1208313-97-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydroxide; In acetonitrile; at 75 - 80 ℃; Reagent/catalyst; Temperature; Solvent;

upstream raw materials:

Methyl (R)-3-hydroxybutyrate

Downstream raw materials:

(R)-3-hydroxybutyric acid

succinic acid

(2E)-but-2-enedioic acid

2.3-butanediol

Refernces

• 1、 -. "Synthesis process of (R)-3-hydroxybutyric acid and salts thereof". Paragraph 0042; 0043. . Retrieved 2017/10/07.