1-(2-BROMOETHYL)-4-FLUOROBENZENE

Base Information

• Chemical Name: 1-(2-BROMOETHYL)-4-FLUOROBENZENE
• CAS No.: 332-42-3
• Molecular Formula: C8H8BrF
• Molecular Weight: 203.054
• Hs Code.: 29039990
• Mol file: 332-42-3.mol

Synonyms:1-(2-Bromoethyl)-4-fluorobenzene;1-Bromo-2-(4-fluorophenyl)ethane;2-(4-Fluorophenyl)ethyl bromide;2-(p-Fluorophenyl)ethyl bromide;4-(2-Bromoethyl)-1-fluorobenzene;

Chemical Property of 1-(2-BROMOETHYL)-4-FLUOROBENZENE

Chemical Property:

• Appearance/Colour: Clear slightly yellow liquid
• Refractive Index: n20/D 1.534(lit.)
• Boiling Point: 209.6 °C at 760 mmHg
• Flash Point: 83.3 °C
• PSA: 0.00000
• Density: 1.454 g/cm³
• LogP: 2.76310
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

4-Fluorophenethyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-51/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the production of protein A mimetics, serotonin antagonists, and other CNS agents

Technology Process of 1-(2-BROMOETHYL)-4-FLUOROBENZENE

There total 11 articles about 1-(2-BROMOETHYL)-4-FLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-Fluorophenyl)ethanol (7589-27-7) → (2-bromoethyl)-4-fluorobenzene (332-42-3)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1.16667h;

DOI:10.1021/jo061154l

Reference yield: 31.0%

2-(4-Fluorophenyl)ethanol (7589-27-7) + phosphorus tribromide (7789-60-8) → (2-bromoethyl)-4-fluorobenzene (332-42-3)

Guidance literature:

In toluene;

Reference yield:

→ (2-bromoethyl)-4-fluorobenzene (332-42-3) + potassium carbonate (584-08-7)

Guidance literature:

upstream raw materials:

2-(4-Fluorophenyl)ethanol

1-(2-bromoethyl)-4-chlorobenzene

4-Fluoro-α-ethylbenzenium ion

p-Fluorophenylacetic acid

Downstream raw materials:

1-(2-bromoethyl)-4-chlorobenzene

4-Fluoro-α-ethylbenzenium ion

[1-(2-benzhydryloxy-ethyl)-piperidin-3-ylmethyl]-[2-(4-fluoro-phenyl)-ethyl]-amine

R-(+)-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

Refernces

• 1、 Galli, Marzia,Fletcher, Catherine J.,Del Pozo, Marc,Goldup, Stephen M.. "Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins". supporting information. p. 5622 - 5626. Retrieved 2016/07/06.
• 2、 -. "SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS". Page/Page column 59. . Retrieved 2012/10/18.