Technology Process of 2-Hydroxyibuprofen
There total 10 articles about 2-Hydroxyibuprofen which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran;
for 1.5h;
under 2585.7 Torr;
Ambient temperature;
DOI:10.1021/jo00314a053
- Guidance literature:
-
With
1H-imidazole; Mn(TDCPP)Cl; dihydrogen peroxide;
In
dichloromethane; acetonitrile;
at 20 ℃;
for 4h;
DOI:10.1248/cpb.50.744
- Guidance literature:
-
Multi-step reaction with 3 steps
1: m-chloroperbenzoic acid / CH2Cl2 / 2 h / 35 °C
2: 1.) potassium tert-butoxide, 2.) HCl / 1.) THF, 15 deg C, 2 h; 2.) THF, 15 deg C, 20 min
3: 100 percent / H2 / Pd/C / tetrahydrofuran / 1.5 h / 2585.7 Torr / Ambient temperature
With
hydrogenchloride; potassium tert-butylate; hydrogen; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00314a053