(R)-3-METHYL-1-HEPTANOL

Base Information

• Chemical Name: (R)-3-METHYL-1-HEPTANOL
• CAS No.: 99427-18-6
• Molecular Formula: C₈H₁₈O
• Molecular Weight: 130.23
• Mol file: 99427-18-6.mol

Synonyms:1-Heptanol,3-methyl-, (R)-;(R)-3-Methyl-1-heptanol;Rhinoceros beetle aggregationpheromone;

Chemical Property of (R)-3-METHYL-1-HEPTANOL

Chemical Property:

• Boiling Point: 179.2 °C at 760 mmHg
• Flash Point: 71.1 °C
• PSA: 20.23000
• Density: 0.821 g/cm³
• LogP: 2.19510

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-3-METHYL-1-HEPTANOL 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-METHYL-1-HEPTANOL

There total 111 articles about (R)-3-METHYL-1-HEPTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-<1-(R)-endo-(1-naphthyl)>bornyl <(S)-3-methyl>heptanoate (106000-05-9) → (S)-3-methylheptan-1-ol (61169-84-4,1070-32-2,99427-18-6,111767-94-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1016/0022-328X(90)80182-Y DOI:10.1016/S0040-4020(01)91033-6

Reference yield: 94.0%

(R)-3-methylheptanoic acid methyl ester (99439-80-2) → (R)-(+)-3-Methyl-1-heptanol (1070-32-2,61169-84-4,111767-94-3,99427-18-6)

Guidance literature:

(R)-3-methylheptanoic acid methyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

With rochelle salt; In tetrahydrofuran; hexane; water;

DOI:10.1002/anie.201002916

Reference yield: 94.0%

(R)-3-methyl-6-hepten-1-ol (237431-14-0) → (R)-(+)-3-Methyl-1-heptanol (1070-32-2,61169-84-4,111767-94-3,99427-18-6)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/ja990918u

upstream raw materials:

(-)(S)-2-methyl-hexane-carboxylic acid-⁽¹⁾-ethyl ester

n-butyl magnesium bromide

(R)-2-(1Ξ,2E)-but-2-enylideneamino-3,3-dimethyl-butyric acid tert-butyl ester

n-butyllithium

Downstream raw materials:

(3S)-methyl-1-tosyloxyheptane

(S)-(+)-14-Methyl-1-octadecene

(R)-3-methylheptanal

(5S,9R)-5,9-dimethyl-8-(4-methylphenylsulfonyl)heptadecane

Refernces

• 1、 Bai, Hongjin,Du, Zhen-Ting,He, Guo-Guo,Liu, Lu,Tang, Meng,Wei, Liang,Zhang, Tao. "A New Asymmetric Synthesis of (S)-14-Methyloctadec-1-ene, the Sex Pheromone of the Peach Leafminer Moth". . p. 1089 - 1095. Retrieved 2020/07/25.
• 2、 Mori, Kenji,Akasaka, Kazuaki. "Pheromone synthesis. Part 256: Synthesis of the four stereoisomers of 5,11-dimethylpentacosane, a new sex pheromone component of the male Galleria mellonella (L.), with high stereochemical purities as determined by the derivatization-HPLC analysis of the eight stereoisomers of 5,11-dimethyl-8-pentacosanol". . p. 4102 - 4115. Retrieved 2015/06/02.