(S)-1-BENZYL-3-MESYLOXY PYRROLIDINE

Base Information

• Chemical Name: (S)-1-BENZYL-3-MESYLOXY PYRROLIDINE
• CAS No.: 118354-71-5
• Molecular Formula: C12H17 N O3 S
• Molecular Weight: 255.338
• Mol file: 118354-71-5.mol

Synonyms:3-Pyrrolidinol,1-(phenylmethyl)-, methanesulfonate (ester), (3S)- (9CI);3-Pyrrolidinol,1-(phenylmethyl)-, methanesulfonate (ester), (S)-;(S)-1-Benzyl-3-methanesulfonyloxypyrrolidine;(S)-Methanesulfonic acid1-benzylpyrrolidin-3-yl ester;(S)-1-Benzyl-3-(mesyloxy)pyrrolidine;

Chemical Property of (S)-1-BENZYL-3-MESYLOXY PYRROLIDINE

Chemical Property:

• PSA: 54.99000
• LogP: 2.25580

Purity/Quality:

98%min ^*data from raw suppliers

(S)-Pyrrolidin-3-yl2-phenylethanesulfonate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-BENZYL-3-MESYLOXY PYRROLIDINE

There total 8 articles about (S)-1-BENZYL-3-MESYLOXY PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-N-benzyl-3-hydroxypyrrolidine (101385-90-4) + methanesulfonyl chloride (124-63-0) → (S)-methanesulfonic acid 1-benzylpyrrolidin-3-yl ester (118354-71-5)

Guidance literature:

With triethylamine; In toluene; at 0 - 20 ℃; for 3.91667h;

Reference yield: 77.5%

(S)-dimethanesulfonate ester 4-chloro-1,3-butanediol + benzylamine (100-46-9) → (S)-methanesulfonic acid 1-benzylpyrrolidin-3-yl ester (118354-71-5)

Guidance literature:

With potassium carbonate; potassium iodide; In tetrahydrofuran; water; for 7.5h; Heating / reflux;

Reference yield:

(S)-N-benzyl-3-hydroxypyrrolidine (101385-90-4) → (S)-methanesulfonic acid 1-benzylpyrrolidin-3-yl ester (118354-71-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; tert-butyl methyl ether;

upstream raw materials:

(S)-N-benzyl-3-hydroxypyrrolidine

methanesulfonyl chloride

(R)-2-Dibenzylamino-butane-1,4-diol

(3S,1'RS)-1-benzyl-3-(1'-ethoxyethyloxy)pyrrolidine

Downstream raw materials:

(R)-1-benzyl-3-(methylamino)pyrrolidine hydrobromic acid salt

(S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate

1-Benzyl-3-aminopyrrolidine

(R)-N-benzyl-3-hydroxypyrrolidine

Refernces

• 1、 Pryde, David C.,Corless, Martin,Fenwick, David R.,Mason, Helen J.,Stammen, Blanda C.,Stephenson, Peter T.,Ellis, David,Bachelor, David,Gordon, David,Barber, Christopher G.,Wood, Anthony,Middleton, Donald S.,Blakemore, David C.,Parsons, Gemma C.,Eastwood, Rachel,Platts, Michelle Y.,Statham, Keith,Paradowski, Kerry A.,Burt, Catherine,Klute, Wolfgang. "The design and discovery of novel amide CCR5 antagonists". supporting information; scheme or table. p. 1084 - 1088. Retrieved 2009/08/07.
• 2、 -. "8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS". Page/Page column 70. . Retrieved 2010/11/25.