PYRIDINE, 2-CHLORO-4-HYDRAZINO-

Base Information

• Chemical Name: PYRIDINE, 2-CHLORO-4-HYDRAZINO-
• CAS No.: 700811-29-6
• Molecular Formula: C5H6 Cl N3
• Molecular Weight: 143.576
• Hs Code.: 2933990090
• Mol file: 700811-29-6.mol

Synonyms:Pyridine,2-chloro-4-hydrazino- (9CI); 2-Chloro-4-hydrazinopyridine

Chemical Property of PYRIDINE, 2-CHLORO-4-HYDRAZINO-

Chemical Property:

• Melting Point: 85-86 °C(Solv: benzene (71-43-2))
• Boiling Point: 308.6±27.0 °C(Predicted)
• PKA: 4.01±0.24(Predicted)
• PSA: 50.94000
• Density: 1.418±0.06 g/cm3(Predicted)
• LogP: 1.79390
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%Min ^*data from raw suppliers

2-Chloro-4-hydrazinopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRIDINE, 2-CHLORO-4-HYDRAZINO-

There total 5 articles about PYRIDINE, 2-CHLORO-4-HYDRAZINO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-4-iodopyridine (153034-86-7) → (2-chloropyridin-4-yl)hydrazine (700811-29-6)

Guidance literature:

With hydrazine;

DOI:10.1016/j.bmcl.2006.04.008

Reference yield: 84.0%

2-chloro-4-bromopyridine (73583-37-6) → (2-chloropyridin-4-yl)hydrazine (700811-29-6)

Guidance literature:

With hydrazine hydrate; at 60 ℃; for 48h; Temperature; Time;

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) → (2-chloropyridin-4-yl)hydrazine (700811-29-6)

Guidance literature:

4-Amino-2-chloropyridine; With sulfuric acid; sodium nitrite; In water; at 0 - 10 ℃; for 0.25h;

With tin(ll) chloride; In water; at 0 - 20 ℃; for 0.5h;

With ammonium hydroxide; In water;

upstream raw materials:

2-chloro-4-iodopyridine

4-Amino-2-chloropyridine

sodium nitrite

2-chloro-4-bromopyridine

Downstream raw materials:

3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-4-carbaldehyde

1-[3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazol-4-yl]ethanol

1-[3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazol-4-yl]ethanone

N-{4-[4-acetyl-3-(2-chlorophenyl)-1H-pyrazol-1-yl]pyridin-2-yl}acetamide

Refernces

• 1、 -. "HETEROARYLS AND USES THEREOF". Paragraph 0887. . Retrieved 2013/07/05.
• 2、 -. "DIAMINOTRIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES". Page 320; 321. . Retrieved 2008/06/13.